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首页> 外文期刊>Neural regeneration research >The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches
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The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches

机译：在中风中使用水凝胶输送的细胞外囊囊泡在卒中中的电动机功能中的回收率：临床翻译的可测试实验假设，包括行为和神经影像评估方法

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Neural tissue engineering, nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system (CNS) repair. It is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes, making development of CNS therapeutics challenging. Given the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society, it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury levels. Extracellular vesicles (EVs), also known as exosomes, when derived from mesenchymal stem cells, are one of the most promising approaches that have been attempted thus far, as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell transplantation. At the same time, advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur, as well as the release of biomolecules facilitating or inducing the reparative processes. This review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable hydrogels. The rationale behind this hypothesis is presented, analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the brain. This sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration occur. Finally, the importance of including non-human primate models in the clinical translation pipeline, as well as the added benefit of multi-modal neuroimaging analysis to establish non-invasive, in vivo, quantifiable imaging-based biomarkers for CNS repair are discussed, aiming for more effective and safe clinical translation of such regenerative therapies to humans.
机译：神经组织工程，纳米技术和神经循环成为近几十年来一直在共同努力的不同生物医学学科，以解决与中枢神经系统（CNS）修复有关的复杂问题。众所周知，由于微环境阻碍了有效的再生过程，使CNS治疗性挑战的显影，因此CNS表现出非常有限的再生能力。鉴于CNS条件的患病率很高，如中风损坏大脑，为受折磨者和社会造成严重负担，最重要的是探讨寻找可以应用于人类以恢复功能的治疗方法的最佳方法伤前度水平。当EVS提供刺激纳米级水平时，作为迄今为止，也称为外泌体的细胞外囊泡（EVS）是迄今为止迄今为止的最有希望的方法之一。与干细胞移植有关的风险。同时，组织工程和再生医学的进步提供了使用水凝胶作为生物支架的潜力，以便提供神经修复所需的基质，以及促进或诱导重复过程的生物分子的释放。本综述介绍了关于可以与生物相容性注射水凝胶结合的益处的新型实验假设。提出了这一假设背后的理由，分析了水凝胶的延长了如何延长EVS的保留并最大限度地提高大脑的局部利益。这种持续交付的EVS将与基本指导提示和来自水凝胶的结构支撑件相结合，直到发生神经组织改造和再生。最后，讨论了在临床翻译管道中包括非人类灵长类动物模型的重要性，以及多模态神经影像分析的增加的益处，以确定非侵入性，在体内，可用于CNS修复的基于CNS修复的生物标志物。更有效和安全的临床翻译对人类的再生疗法。

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