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Sudden-onset Encephalopathy: Do not ignore the Possibility of Hashimoto's Encephalopathy

机译:突然发作的脑病:不要忽视哈希莫病的脑病的可能性

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Hashimoto's encephalopathy (HE) is an uncommon neurological disorder of unknown etiology, found in association with thyroid autoimmunity, mostly uncommon in males. The disease occurs primarily in the fifth decade of life and may occur in two forms; a sudden vasculitic type or a progressive subacute type associated with cognitive dysfunction, confusion, and memory loss. We report a case of a 51-year-old Sri Lankan gentleman with no comorbidities who was presented with one episode of the generalized tonic- clonic seizure (GTCs) followed by prolonged agitation and disorientation. His EEG showed generalized slowing while CT scan and MRI brain were unremarkable. CSF examination showed high protein level with normal cell count and glucose. Routine serologic examination showed very high thyroid-stimulating hormone (TSH) level, with significantly high antithyroid antibodies. He was diagnosed as a case of Hashimoto's encephalopathy and treated with a high dose of steroid and showed remarkable improvement.
机译:Hashimoto的脑病(他)是一种罕见的神经障碍未知病因,与甲状腺自身免疫有关,在雄性中大多罕见。该疾病主要发生在生命的第五十年中,可能以两种形式发生;突然的血管型或与认知功能障碍,混淆和记忆损失相关的渐进亚急性类型。我们举报了一个51岁的Sri Lankan绅士,没有合并症,他们被呈现出一集的普通滋补克隆癫痫发作(GTCS),然后延长搅动和迷失方向。他的脑电图显示了广泛的放缓,而CT扫描和MRI大脑未解重。 CSF检查显示出高蛋白质水平,具有正常的细胞计数和葡萄糖。常规血清素检查显示出非常高的甲状腺刺激激素(TSH)水平,具有显着高的抗胆汁抗体。他被诊断为哈希莫病的脑病,并用高剂量的类固醇治疗,并显示出显着的改善。

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