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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Neurobehavioral deficits in progressive experimental hydrocephalus in neonatal rats
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Neurobehavioral deficits in progressive experimental hydrocephalus in neonatal rats

机译：新生大鼠进行性实验性脑积水中的神经麻烦缺陷

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Hydrocephalus is usually associated with functional deficits which can be assessed by neurobehavioral tests. This study characterizes the neurobehavioral deficits occurring with increasing duration and severity of ventriculomegaly in an? experimental neonatal hydrocephalic rat model. Hydrocephalus was induced in three weeks old albino rats by intracisternal injection of kaolin while controls received sterile water injection. They were sacrificed in batches at one, four and eight weeks post-injection after neurobehavioral tests (forelimb grip strength, open field and Morris water maze tests) were performed. The hydrocephalic rats were also? categorized into mild, moderate and severe hydrocephalus based on ventricular size. The indices of muscular strength and vertical movements in severely hydrocephalic rats were 28.05 ± 5.19 seconds and 7.29 ± 2.71 rearings respectively, compared to controls (75.68 ± 8.58 seconds and 17.09 ± 1.25 rearings respectively). At eight weeks, vertical movements were significantly reduced in hydrocephalic rats compared to controls (3.14 ± 1.3 vs 13 ± 4.11 rearings). At one week, indices of learning and memory were significantly reduced in hydrocephalic rats, compared to controls (0.89±0.31 vs 3.88±1.01 crossings), but at 8 weeks, the indices were similar (2.56 ± 0.41 vs 3.33 ± 0.71 crossings). Untreated hydrocephalus is accompanied by decline in motor functions which increase with duration and severity of ventriculomegaly. However, cognitive deficits appear to partially recover.
机译：脑积水通常与功能缺陷相关，其可以通过神经兽性测试评估。本研究表征了随着腹腔内的持续时间和严重程度发生的神经表达缺陷？实验新生儿脑脑大鼠模型。通过脑内注射高岭土，在三个星期的白化大鼠中诱导脑积水，同时对照进行无菌注水。在进行神经兽性试验（前肢抓地力，开放场和Morris水迷宫测试后，在注射后一批，四个和八周处于批次中处死。脑脑大鼠也呢？基于心室大小分类为轻度，中度和严重的脑积水。与对照相比，严重脑脑大鼠肌肉强度和垂直运动的指数分别为28.05±5.19秒和7.29±2.71次培训（分别为75.68±8.58秒和17.09±1.25级）。八周，与对照相比，脑脑大鼠中垂直运动显着降低了（3.14±1.3±4.11±4.11升级）。在一周的情况下，与对照相比，脑脑大鼠中学习和记忆指数（0.89±0.31 Vs 3.88±1.01交叉点），但在8周内，指数相似（2.56±0.41与3.33±0.71交叉口）。未经治疗的脑积水伴随着运动功能的下降，随着脑室细胞的持续时间和严重程度而增加。但是，认知缺陷似乎部分恢复。

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