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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Ahaptoglobinaemia in a Nigerian cohort
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Ahaptoglobinaemia in a Nigerian cohort

机译：尼日利亚队列的AhapToglobina血症

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Ahaptoglobinaemia have been indicated in blacks from West Africa. Owing to the clinical and biologic importance of haptoglobin (hpt), this work explores the situation in a Nigerian cohort since there are no published values of haptoglobin levels of individuals in this locality. The study was aimed at determining the amount of haptoglobin in the blood of normal healthy Nigerians. Haptoglobin was quantitatively estimated in one hundred and fifty-two apparently healthy individuals using highly sensitive immunoassay technology. Blood grouping and haemoglobin genotype were assayed for all subjects to know if they influence haptoglobin levels. The association between haptoglobin and blood group was also established. Serum levels of haptoglobin among all subjects analyzed revealed a marked decrease in their haptoglobin levels when compared to other reference intervals. A further association between haptoglobin and gender did not reveal a statistical significant relationship (p0.05). However, there was a significant different when haptoglobin levels of different blood groups and haemoglobin genotype when compared. Our data suggest that serum levels of haptoglobin are significantly lower in healthy Nigerians. The lower limit was remarkably lower than the internationally acceptable Caucasian reference range suggesting a clear necessity for establishing reference African values.
机译：AhapToglobina血症已被西非的黑人表明。由于哈达福林（HPT）的临床和生物学重要性，这项工作探讨了尼日利亚队列的情况，因为这条目中没有出版的哈帕伯宾级的哈帕莫林级别。该研究旨在确定正常健康尼日利亚血液中的血红蛋白量。使用高度敏感的免疫测定技术，在一百五十二个明显健康的个体中定量估计了哈达福蛋白。为所有受试者测定血液分组和血红蛋白基因型，以知道它们是否影响赤霉素水平。还建立了赤膜蛋白和血型组织。与其他参考间隔相比，分析的所有受试者中，分析的所有受试者之间的血清抗ogloglogin的血清水平揭示了它们的颤膜蛋白水平的显着降低。哈达福林和性别之间的进一步关联没有揭示统计显着关系（p> 0.05）。然而，当相比时，当不同血液群和血红蛋白基因型的哈达福林水平时显着差异。我们的数据表明，健康的尼日利亚人的血清抗oglobin水平显着降低。下限比国际可接受的白种人参考范围显着低，表明建立参考非洲价值观的清晰必要性。

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