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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Salivary electrolytes, total protein and immunoglobulin a in patients with chronic kidney disease: A case control study
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Salivary electrolytes, total protein and immunoglobulin a in patients with chronic kidney disease: A case control study

机译:慢性肾病患者唾液电解质,总蛋白质和免疫球蛋白A:案例对照研究

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The objectives of this study were to compare levels salivary electrolytes, total protein and immunoglobulin A (IgA) in patients with chronic kidney disease (CKD) and healthy individuals; and to determine the relationship between the salivary and blood levels of these factors between the two groups. Ninety-eight participants consisting of 48 patients with CKD and 50 healthy individuals (age and gender matched) were included. Whole saliva and blood samples were collected and analyzed for concentrations of electrolytes (K+, Na+, Ca2+, Cl-, and HCO32-), total protein and IgA. Data were analyzed using Independent-Samples t-test and Pearson correlation test. Concentrations of salivary K+, Ca2+, Cl-, and total protein were higher; while concentrations of salivary Na+, HCO32- were lower in patients with CKD compared with healthy individuals. There was no difference in the salivary IgA levels in patients with CKD compared with healthy individuals. Salivary calcium level showed linear correlation with the plasma calcium level while salivary chloride level showed negative correlation with plasma chloride level among patients with CKD. These findings indicate that saliva and plasma from patients with CKD are characterized by higher potassium, chloride, and lower sodium concentrations than their levels in healthy individuals; thus, suggesting a possible increased adrenal-cortical activity in patients with CKD.
机译:本研究的目的是将慢性肾病(CKD)和健康个体患者中的水平唾液电解质,总蛋白和免疫球蛋白A(IgA)进行比较;并确定两组之间这些因素的唾液和血液水平之间的关系。包括48名患有48例CKD和50名健康个体(年龄和性别匹配)的九十八名参与者。收集整个唾液和血液样品,并分析电解质(K +,Na +,Ca2 +,Cl-和HCO32-),总蛋白和IgA的浓度。使用独立样本T检验和Pearson相关试验分析数据。唾液K +,Ca2 +,Cl-和总蛋白质的浓度较高;虽然唾液Na +,HCO32-与健康个体相比,CKD患者的患者较低。与健康个体相比,CKD患者的唾液IgA水平没有差异。唾液钙水平显示与血浆钙水平的线性相关性,而唾液氯化物水平表现出CKD患者患者血浆氯化物水平的负相关性。这些发现表明,CKD患者的唾液和血浆的特征在于钾,氯化钾和较低的钠浓度,而不是健康个体的水平;因此,表明CKD患者可能增加的肾上腺皮质活性。

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