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Naturally enriched 13 C breath test as a carbohydrate intake marker in obese women

机译：当然富集的13 C呼吸测试作为肥胖女性的碳水化合物进气标记物

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BackgroundThe sup13/supC breath test has been proposed as a potential biomarker for the evaluation of metabolism and carbohydrate intake. To study the dynamics of the use of substrates in human metabolism is especially important for glucose metabolism in obese people.PurposeThis study aimed to verify the use of sup13/supC in a naturally enriched corn glucose liquid meal through the breath test as a potential marker of energy metabolism in women with a body mass index (BMI) above 35?kg /msup2/sup.MethodsTwenty-five woman (13 non-obese; 12 obese) participated in the study. The breath samples were collected in tubes prior to consumption of the standard liquid meal and at 30-min intervals for 6?h and analyzed in a continuous flow isotope ratio mass spectrometer. The curves of breath isotopic enrichment were adjusted by the Boltzmann sigmoidal regression model, and the t test was used to evaluate differences between the means of the curves.ResultsIt was found a faster metabolic turn-over of the sup13/supC-glucose in obese women.ConclusionThe breath test using naturally enriched stable isotopes has potential to be used as an energy metabolism marker in subjects with different BMI.
机译：背景技术已经提出了用于评估代谢和碳水化合物摄入的潜在生物标志物。为研究人类代谢中使用底物的动态对于肥胖人群的葡萄糖代谢尤为重要.Purposethis研究旨在通过呼吸来验证在天然富集的玉米葡萄糖液体粉中使用 13-sup> c测试作为体重指数（BMI）的女性能量代谢的潜在标记以上35？kg / m< sup -22'/sup>。方法（13个非肥胖; 12肥胖）参加了这项研究。在将标准液体粉末和30分钟的间隔消耗之前在管中收集呼吸样品，并以6ΩH为单位，并在连续流动同位素比质谱仪中分析。通过Boltzmann Sigmoider回归模型调整了呼吸同位素富集的曲线，使用T检验来评估曲线的装置之间的差异。发现了 13 的速度更快的代谢转弯。 C-肥胖的肥胖妇女。结论使用天然富集的稳定同位素的呼气试验具有用作不同BMI的受试者的能量代谢标志物。

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