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首页> 外文期刊>Research Journal of Health Sciences >Urinary Assessment among Nigerians in Health and with Frequent Use of Non-steroidal Anti-inflammatory Drugs
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Urinary Assessment among Nigerians in Health and with Frequent Use of Non-steroidal Anti-inflammatory Drugs

机译：尼日利亚人的健康和频繁使用非甾体抗炎药物的尿辨率评估

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Background: Proteinuria is a risk factor for the occurrence and progression of chronic kidney disease hence its use in screening, diagnosis and monitoring purposes. The use of untimed sample has become more common due to shortcomings associated with 24 hour urine collection.Aim: To use urinary measures in comparing the kidney function of a healthy population with an apparently healthy population with frequent use of non-steroidal anti-inflammatory drugs (NSAIDs).Methods: Two hundred participants submitted paired urine samples. Blood was collected for estimation of creatinine based glomerular filtration rate (GFR). Student t-test and Chi-square tests were used to compare means and proportions respectively.Result: The prevalence of kidney dysfunction among NSAIDs users using eGFR, albumin creatinine ratio (ACR), protein creatinine ratio (PCR) and 24 hour urine protein (24HUP) were 22%, 18%, 16% and 11% while in the controls were 6%, 6%, 5% and 0% respectively. The albumin creatinine ratio (ACR) was most strongly correlated with GFR in NSAIDs users.Conclusion: The prevalence of kidney dysfunction using eGFR, ACR, PCR and 24HUP in NSAIDs users were all higher than in the healthy controls. The correlation between GFR and ACR was strongest of all urinary measures hence the ACR was a more reliable measure of kidney function assessment in health and in frequent NSAIDs use.
机译：背景：蛋白尿是慢性肾病的发生和进展的危险因素，从而在筛选，诊断和监测目的中使用。由于与24小时尿液收集相关的缺点，使用未定量的样品变得更加常见。使用尿液措施，以比较健康人群的肾功能，具有频繁使用非甾体类抗炎药物（NSAIDS）。方法：两百名参与者提交了配对的尿样。收集血液以估计基于肌酐的肾小球过滤速率（GFR）。学生T检验和Chi-Square测试分别进行比较和比例。结果：使用EGFR，白蛋白肌酐比（ACR），蛋白质肌酐比（PCR）和24小时尿蛋白（ 24hup）在对照中分别为22％，18％，16％和11％，分别为6％，6％，5％和0％。白蛋白肌酐比率（ACR）与NSAIDS用户的GFR最强烈地相关。结论：使用EGFR，ACR，PCR和24hUP在NSAIDS用户中的肾功能障碍的患病率全部高于健康对照。 GFR与ACR之间的相关性最为困难，因此ACR是一种更可靠的肾功能评估衡量健康和频繁的NSAIDS使用。

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