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首页> 外文期刊>Research Letters in Biochemistry >In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice
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In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice

机译：在80％甲醇的体内抗疟疾活性和常系棕色FRESEN的含水树皮提取物。 （Combretaceae）对小鼠的反对疟原虫

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Background. Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. Evergrowing resistance towards the currently available antimalarial drugs is a challenge to combat malaria. Medicinal plants are a promising source of new drugs to tackle this problem. Thus, the present study aimed at evaluating the antiplasmodial activity of Terminalia brownii in Plasmodium berghei infected mice. Methods. A 4-day suppressive test was employed to evaluate the antimalarial effect of 80% methanol and aqueous bark extracts of T. brownii against P. berghei in Swiss albino mice. Results. The in vivo acute toxicity test indicated that both extracts of T. brownii did not cause mortality. The 4-day early infection test revealed that the 80% methanol and aqueous extracts exhibited a significant inhibition of parasitemia compared to negative control. The maximum level of chemosuppression (60.2%) was exhibited at 400?mg/kg dose of 80% methanol extract. Moreover, the 80% methanol extract showed a significant attenuation of anemia associated with infection in a dose-dependent manner. The aqueous extract, on the other hand, exhibited a percent inhibition of 51.1% at the highest dose (400?mg/kg/day). Conclusion. The present study indicated that hydromethanolic and aqueous bark extracts of T. brownii possess a promising antimalarial activity, with higher effect exhibited by the hydromethanolic extract.
机译：背景。尽管在过去的二十年中，尽管有着实质性的科学进步，但疟疾仍然是全世界的负担。对目前可用的抗疟疾药物的常绿抗性是对抗疟疾的挑战。药用植物是一个有前途的新药来源，以解决这个问题。因此，目前的研究旨在评估疟原虫在Perghei感染的小鼠中常年棕榈霉素的抗癌症活性。方法。使用4天的抑制试验来评估瑞士白化小鼠的80％甲醇和水树皮提取物的抗疟疾效果。结果。体内急性毒性试验表明，T.Brownii的提取物都没有引起死亡率。 4天早期感染检测显示，与阴性对照相比，80％甲醇和含水提取物表现出对寄生虫的显着抑制。在400×Mg / kg剂量为80％甲醇提取物中表现出最大化学抑制水平（60.2％）。此外，80％甲醇提取物显示出以剂量依赖性方式与感染相关的贫血的显着衰减。另一方面，含水提取物在最高剂量（400×mg / kg /天）处显​​示出51.1％的抑制百分比。结论。本研究表明，T.Brownii的升级甲烷和水树皮提取物具有有前途的抗疟活性，具有较高的升级效果提取物。

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