首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Leucemia linfoide cr?3nica de c??lulas B: revisi?3n de sus aspectos etiopatog??nicos, moleculares y pron?3sticos
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Leucemia linfoide cr?3nica de c??lulas B: revisi?3n de sus aspectos etiopatog??nicos, moleculares y pron?3sticos

机译:Linfoide Leucemia CRI LLAS B:修订埃塞俄比亚特顾名思,分子和利润

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Chronic lymphocytic leukemia (CLL) is a malignancy that mainly affects middle-aged and elderly patients. It is characterized by the proliferation of morphologically mature but immunoincompetent lymphocytes that accumulate in blood, bone marrow and lymphatic tissue. It presents great clinical heterogeneity. Several phenotypes are described, although the clonal expansion of CD5 + CD23 + B cells predominates. Prognostic factors include the cytogenetic subgroup, immunoglobulin mutational status, expression of ZAP-70, CD38, and CD49d. The treatment is based on using modern approved therapeutic algorithms that produce greater responses and minor secondary events, to achieve complete clinical remission and to improve the quality of life of these patients.
机译:慢性淋巴细胞白血病(CLL)是一个恶性肿瘤,主要影响中年和老年患者。它的特征在于在血液,骨髓和淋巴组织中积聚的形态学性成熟但免疫型淋巴细胞的增殖。它呈现出巨大的临床异质性。描述了几种表型,尽管CD5 + CD23 + B细胞的克隆膨胀主要是占优势的。预后因子包括细胞遗传学亚组,免疫球蛋白突变状态,ZAP-70,CD38和CD49D的表达。该治疗基于使用现代批准的治疗算法,产生更大的反应和次要的次要事件,以实现完整的临床缓解,并提高这些患者的生活质量。

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