首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Anticuerpos antiplaquetarios en pacientes cubanos en espera de trasplante renal
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Anticuerpos antiplaquetarios en pacientes cubanos en espera de trasplante renal

机译:古巴患者等待肾移植的抗蛋白抗体

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Introduction: Platelet-specific antigens, known as human platelet antigens (HPA), are included within the spectrum of non-HLA histocompatibility antigens, because HPA antibodies participate in the rejection of transplantation, besides being a cause of the phenomenon of platelet refractoriness. Objective: To characterize antibodies against platelet-specific antigens in Cuban patients awaiting kidney transplantation. Methods: The technique “monoclonal antibodies immobilized platelets antigens" was applied to blood samples from 901 patients. Results: HPA antibodies were detected in 78 patients, which in 87.17 % recognized the antigens present in the GP-IIb / IIIa complex. These antibodies were in 78.2 % of the IgG class, in 11.53 % IgA and IgM in 46.15 %. Conclusions: HPA antibodies, mostly of the IgG class and directed to antigens present in the GP-IIb/IIIa complex, are common in Cuban patients awaiting kidney transplantation.
机译:介绍:血小板特异性抗原,称为人血小板抗原(HPA),包括在非HLA组织相容性抗原的光谱内,因为HPA抗体参与移植的排斥,除了是血小板耐火性现象的原因。目的:鉴于等待肾移植的古巴患者对血小板特异性抗原的抗体。方法:将该技术“单克隆抗体固定化血小板抗原”应用于901例血液样本。结果:78例患者中检测到HPA抗体,其中87.17%识别出GP-IIB / IIIA复合物中存在的抗原。这些抗体是在78.2%的IgG类中,11.53%IgA和IgM,46.15%。结论:HPA抗体主要是IgG类,并指向GP-IIB / IIIA复合物中存在的抗原,在等待肾移植的古巴患者中常见。

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