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A “One-Health” approach for diagnosis and molecular characterization of SARS-CoV-2 in Italy

机译:意大利SARS-COV-2诊断和分子表征的“一种健康”方法

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The current pandemic is caused by a novel coronavirus (CoV) called SARS-CoV-2 (speciesSevere acute respiratory syndrome-related coronavirus, subgenusSarbecovirus, genusBetacoronavirus, familyCoronaviridae). In Italy, up to the 2nd of April 2020, overall 139,422 confirmed cases and 17,669 deaths have been notified, while 26,491 people have recovered. Besides the overloading of hospitals, another issue to face was the capacity to perform thousands of tests per day. In this perspective, to support the National Health Care System and to minimize the impact of this rapidly spreading virus, the Italian Ministry of Health involved the Istituti Zooprofilattici Sperimentali (IZSs), Veterinary Public Health Institutes, in the diagnosis of SARS-CoV-2 by testing human samples. The Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise is currently testing more than 600 samples per day and performing whole genome sequencing from positive samples. Sequence analysis of these samples suggested that different viral variants may be circulating in Italy, and so in Abruzzo region. CoVs, and related diseases, are well known to veterinarians since decades. The experience that veterinarians operating within the Public Health system gained in the control and characterization of previous health issues of livestock and poultry including avian flu, bluetongue, foot and mouth disease, responsible for huge economic losses, is certainly of great help to minimize the impact of this global crisis.
机译:目前的大流行是由称为SARS-COV-2的新型冠状病毒(COV)引起(Speciesesevere急性呼吸综合征相关的冠状病毒,亚因血清病毒,Genusbetacoronavirus,Fourstcoronaviridae)。在意大利,高达4月20日,总共139,422案确认案例,并已通知17,669人死亡,而26,491人则恢复过。除了医院的过载,面临的另一个问题是每天执行数千项测试的问题。在这种观点中,为了支持国家卫生保健系统,并尽量减少这种迅速传播病毒的影响,意大利卫生部涉及伊特特·Zooprofilattici Sperishi(IZS),兽医公共卫生机构,在SARS-COV-2的诊断中通过测试人类样品。 Istituto Zooprofilattico Sperimentale Dell'abruzzo e Del Molise目前每天测试超过600个样品,并从阳性样品进行全基因组测序。这些样品的序列分析表明,不同的病毒变体可以在意大利循环,并且在Abruzzo地区。 CoVS和相关疾病以来是自十年以来的兽医众所周知的。兽医在畜牧业和家禽禽流感的畜禽卫生问题中获得的公共卫生系统内运营的经验,包括禽流感,BlueTongue,脚和口病,负责巨大的经济损失,肯定有很大的帮助,尽量减少影响这个全球危机。

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