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首页> 外文期刊>Open Journal of Veterinary Medicine >Canine Herpesvirus Latent Infection in Experimentally Infected Rabbits
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Canine Herpesvirus Latent Infection in Experimentally Infected Rabbits

机译：犬疱疹病毒在实验感染的兔子潜在感染

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An experimental inoculation of canine Herpesvirus (HVC), strain H17, was performed in rabbits previously and simultaneously treated with dexamethasone, the behavior of the leukocyte count was followed prior and during the experimental phase. Upon death or euthanasia of the animals, a necropsy and evaluation of various organs was performed by histopathology and by nested PCR against the Herpesvirus Polymerase gene. All animals inoculated with dexamethasone showed leukopenia (p < 0.05), animals inoculated with HVC and treated with dexamethasone did not show significant histological lesions, but showed amplification of the Herpesvirus Polymerase gene in various organs despite not showing clinical signs of the illness. A dolphin Herpesvirus isolate was used as a positive control as rabbits developed fatal systemic disease and lesions typical of active (lytic) infection in various organs within 72 hours post-inoculation. The absence of clinical signs, significant histological lesions, and the presence of viral DNA in some organs suggested a state of latency due to canine Herpesvirus. Dexamethasone allowed HVC infection, but did not promote viral reactivation in rabbits contrary to that observed in canines experimentally induced to the lytic cycle by HVC.
机译：在先前的兔子中进行犬疱疹病毒（HVC），菌株H17的实验接种，并同时用地塞米松治疗，在实验阶段之前和在实验阶段进行白细胞计数的行为。在动物的死亡或安乐死时，通过组织病理学和嵌套的PCR对疱疹病毒聚合酶基因进行尸检和各种器官的评价。所有动物接种用地塞米松都显示白细胞减少（P <0.05），用HVC接种并用地塞米松处理的动物没有显示出显着的组织学病变，但尽管未显示出疾病的临床症状，但表现出在各种器官中扩增Herpesvirus聚合酶基因。用兔子在接种后72小时内发育致命的全身疾病和典型活性（裂解）感染的致命全身性病和病变，兔阳性对照阳性对照。在一些器官中没有临床症状，显着的组织学病变和病毒DNA的存在表明犬疱疹病毒引起的潜伏状态。地塞米松允许HVC感染，但未促进兔中的病毒再活化与在通过HVC通过实验诱导的碱循环观察到的犬观察到。

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