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首页> 外文期刊>Obesity facts : the European journal of obesity. >Association between CST3 rs2424577 Polymorphism and Corpulence Related Phenotypes during Lifetime in Populations of European Ancestry
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Association between CST3 rs2424577 Polymorphism and Corpulence Related Phenotypes during Lifetime in Populations of European Ancestry

机译：CST3 RS2424577在欧洲血统群体中的多态性和养殖相关表型的关系

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Objective: Cystatin C, a protein coded by CST3 gene, is implicated in adipose tissue biology. Our hypothesis is that common variants in CST3 gene could play a role in the development of corpulence during lifetime. Methods: Two tag SNPs were selected to capture all SNPs in the CST3 region. We first investigated the association of the two tag SNPs individually and combined into haplotypes with corpulence related phenotypes in 4,288 French subjects (BMI = 24.31 ( 3.74 kg/m2). Significant findings were replicated in five independent populations – 790 Danish lean men (BMI = 24.63 ( 2.30 kg/m2), 672 Danish obese men (BMI = 33.23 ( 2.34 kg/m2), 763 Swedish women (BMI = 21.73 ( 2.87 kg/m2), 1,848 Danish lean women (BMI = 22.66 ( 2.85 kg/m2) and 2,061 Danish obese women (BMI = 37.01 ( 3.59 kg/m2). Results: Rs2424577 was associated with BMI in three independent populations – G/G carriers were less corpulent than A/A carriers in the French individuals (p = 0.045) and in the Danish lean men (p = 0.021), and they were more corpulent in the group of Swedish women (p = 0.004). This phenomenon has been described as a flip-flop phenomenon, probably caused by a multilocus effect. Conclusion: CST3 rs2424577 is associated with BMI in a complex fashion. This association is probably caused by the interaction between several functional variants.
机译：目的：胱抑素C是CST3基因编码的蛋白质，涉及脂肪组织生物学。我们的假设是CST3基因中的常见变体可以在寿命期间酿造的发展中发挥作用。方法：选择两个标签SNP以捕获CST3区域中的所有SNP。我们首先调查了两款标签SNP的关联，并将单倍型与腐殖型相关表型在4,288个法国受试者中（BMI = 24.31（3.74kg / m 2 ）。在五个独立人群中复制了重要发现 - 790丹麦瘦男人（BMI = 24.63（2.30公斤/米 2 ），672丹麦肥胖男士（BMI = 33.23（2.34千克/ m 2 ），763瑞典女性（BMI = 21.73（2.87 kg / m 2 ），1,848名丹麦瘦女性（BMI = 22.66（2.85 kg / m 2 ）和2,061名丹麦肥胖女性（BMI = 37.01 （3.59 kg / m 2 ）。结果：RS2424577在三个独立的人群中与BMI相关联 - G / G载体比法国人（P = 0.045）的载体少于A / A载体丹麦精益男性（P = 0.021），它们在瑞典女性组中更具肥力（P = 0.004）。这种现象被描述为触发器现象，可能是由多点效应引起的。结论：CST3 RS2424577是相关的Wi. Th BMI以复杂的方式。该关联可能是由几种功能变体之间的相互作用引起的。

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