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首页> 外文期刊>Obesity facts : the European journal of obesity. >Predictors of Subclinical Inflammatory Obesity: Plasma Levels of Leptin, Very Low-Density Lipoprotein Cholesterol and CD14 Expression of CD16+ Monocytes
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Predictors of Subclinical Inflammatory Obesity: Plasma Levels of Leptin, Very Low-Density Lipoprotein Cholesterol and CD14 Expression of CD16+ Monocytes

机译：亚临床炎症性肥胖的预测因素：瘦蛋白的血浆水平，非常低密度脂蛋白胆固醇和CD14表达CD16 +单核细胞

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Objective : Predictors of subclinical inflammatory obesity (SIO) can be important tools for early therapeutic interventions in obesity-related comorbidities. Waist circumference (WC) and BMI have different SIO sensitivity. We aimed to i) identify SIO predictors and ii) investigate whether CD16+ monocytes are associated with BMI- (generally) or WC-defined (centrally) obesity. Methods : Anthropometric and metabolic/endocrine (namely catecholamines, adrenaline and noradrenaline) parameters were evaluated, and CD16+ monocytes were studied by flow cytometry in the peripheral blood from 63 blood donors, and compared and correlated to each other. Multiple linear regression analysis was performed to identify variables that best predict SIO. Results : CD16+ monocyte counts were similar in BMI and WC groups. CD16+ monocytes from centrally obese (CO) showed a more inflammatory pattern, as compared to non-CO subjects. WC was sensitive to lipidemia and, in CO subjects, lipidemia was associated with a more inflammatory phenotype of CD16+ monocytes. These differences were not noticed between BMI groups. Adrenaline was correlated with CD16+ monocyte expansion with a lower inflammatory pattern. Leptin, very low-density lipoprotein cholesterol (VLDL-C), and CD14 expression of CD16+ monocytes were found to be CO predictors. Conclusions : WC-, but not BMI-defined obesity, was associated with a more inflammatory pattern of CD16+ monocytes, without monocyte expansion, suggesting that a monocyte maturation process rather than an independent arise of CD16+ monocytes occurs in CO. Thus, in a population with low cardiovascular risk, leptin, VLDL-C, and CD14 expression of CD16+ monocytes predict CO, constituting a putative tool for screening of SIO.
机译：目的：亚临床炎症性肥胖的预测因子（SIO）可以是肥胖相关的合并症的早期治疗干预的重要工具。腰围（WC）和BMI具有不同的SiO敏感性。我们的目标是i）鉴定SiO预测因子和II）调查CD16 +单核细胞是否与BMI-（通常）或WC定义（集中）肥胖有关。方法：评价人体测定和代谢/内分泌（即，儿茶酚胺，肾上腺素和去甲肾上腺素）参数，并通过63献血器的外周血流式细胞术研究CD16 +单核细胞，并与彼此进行比较和相关。进行多元线性回归分析以识别最佳预测SIO的变量。结果：BMI和WC组中CD16 +单核细胞计数相似。与非CO受试者相比，来自中心肥胖（CO）的CD16 +单核细胞显示出更炎症的模式。 WC对血脂症敏感，在CO受试者中，血脂症与CD16 +单核细胞的更炎症表型相关。 BMI组之间没有注意到这些差异。肾上腺素与CD16 +单核细胞膨胀相关，炎症图案较低。瘦素，非常低密度的脂蛋白胆固醇（VLDL-C）和CD14表达CD16 +单核细胞的表达是CO预测因子。结论：WC-但不是BMI定义的肥胖，与没有单核细胞膨胀的CD16 +单核细胞的更炎症模式相关，表明单核细胞成熟过程而不是独立的CD16 +单核细胞出现的CO.因此，在群体中发生具有低心血管风险，瘦素，VLDL-C和CD14表达CD16 +单核细胞预测CO，构成了用于筛选SIO的推定工具。

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