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首页> 外文期刊>Open Journal of Pathology >Primary Ovarian Carcinosarcoma: Cytological, Pathological, Immunocytochemical, and Immunohistochemical Features
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Primary Ovarian Carcinosarcoma: Cytological, Pathological, Immunocytochemical, and Immunohistochemical Features

机译：原发性卵巢癌：细胞学，病理，免疫细胞化学和免疫组化特征

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摘要

Ovarian carcinosarcoma composed of high-grade carcinoma and sarcoma is an extremely rare neoplasm and typically occurs in postmenopausal women aged over 60 years. A 73-year-old female, gravida three para three, presented to our hospital with right lower abdominal pain. Right pelvic solid tumor with ascites was detected on pelvic ultrasound examination. She underwent hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy, but the tumor had invaded to the right ureter, and some fragile tumor could not be taken (sub-optimal surgery). On the imprint and ascitic cytology specimens during operation, atypical cells suggestive of adenocarcinoma and spindle atypical cells with immunocytochemically vimentin positive were found. The resected tumor was histopathologically carcinosarcoma consisted of serous adenocarcinoma, chondrosarcoma and fibrosarcoma. Immunohistochemical analysis revealed that adenocarcinoma cells were positive for AE1/AE3 and fibrosarcoma cells stained with vimentin. The final diagnosis was the right ovarian carcinosarcoma (stage pT3CNxMx). Microsatellite instability was stable and BRCA1/2 mutations could not be found in the carcinosarcoma cells. The patient was given four cycles of chemotherapy with paclitaxel, carboplatin and bevacizumab regimen, and thereafter she was treated with the ifosfamide and cisplatin because of slight elevation of serum CA125.
机译：由高级癌和肉瘤组成的卵巢癌是一种极其罕见的肿瘤，通常发生在60多年以上的绝经后妇女。一个73岁的女性，比赛三个第三段，呈现给我们的医院，右下腹部疼痛。在盆腔超声检查上检测到右盆腔固体肿瘤。她接受了子宫切除术，双侧Salpingo-Oophorectomy和部分缺斑术，但肿瘤已侵入右输尿管，并且可以缺乏一些脆弱的肿瘤（次良好的手术）。在手术过程中的印记和腹水细胞学标本上，发现了具有免疫细胞改性阳性的腺癌和主轴非典型细胞的非典型细胞。切除的肿瘤是组织病理学上的癌症，包括浆液性腺癌，软骨肉瘤和纤维肉瘤组成。免疫组织化学分析表明，腺癌细胞对AE1 / AE3的阳性和用VimentIn染色的纤维肉瘤细胞。最终的诊断是正确的卵巢癌（PT3CNXMX）。微卫星不稳定性是稳定的，并且在癌细胞中找不到BRCA1 / 2突变。患者对紫杉醇，卡铂和Bevacizumab方案进行了四个化疗的化疗，此后，由于血清Ca125的轻微升高，她用IFOSFamide和顺铂治疗。

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