Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

Michael L Gatza; Julie C Watt; Susan J Marriott

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Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

机译：HTLV-i税收蛋白的细胞转化，一流的交易

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The human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that is responsible for adult T-cell leukemia and a neurological disease, HTLV-I-associated myelopathy/tropical spastic paraparesis. HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellular functions prompting it to be referred to as a jack-of-all trades. The ability of Tax to both transcriptionally regulate cellular gene expression and to functionally inactivate proteins involved in cell-cycle progression and DNA repair provide the basis for Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects of Tax on the dysregulation of the G1/S and G2/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation.

机译：人T细胞白血病病毒I型（HTLV-I）是一种致癌病毒，负责成人T细胞白血病和神经疾病，HTLV-I相关的肌蛋胨/热带痉挛性痉挛。 HTLV-I编码致癌蛋白，税收，影响各种蜂窝功能，提示它被称为所有交易。转录调节细胞基因表达的税收能力和在细胞周期进展和DNA修复中的功能灭活蛋白质提供税介导的转化和白血病的基础。本综述将集中纳税对G1 / s和G2 / M检查点的失调的影响以及导致细胞转化的DNA损伤修复的抑制。

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《Oncogene》 |2003年第33期|共9页
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Michael L Gatza; Julie C Watt; Susan J Marriott;
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1. Transcriptional Activity of HTLV-I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation [J] . Francene J.Lemoine, Diane R.Wycuff, Susan J.Marriott Disease markers . 2001,第3期

机译：HTLV-I税收的转录活动影响与细胞转化相关的标记基因的表达。
2. The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions [J] . Wolfgang Nacken, Martin Klempt, Clemens Sorg Biochimica et biophysica acta. Gene structure and expression . 1995,第3期

机译：HTLV-I税务反应元件结合蛋白TAXREB107的小鼠同源物是高度保守的基因，可能调节一些基础细胞功能
3. Longer dinucleotide repeat polymorphism in matrix metalloproteinase-9 (MMP-9) gene promoter which correlates with higher HTLV-I Tax mediated transcriptional activity influences the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HA [J] . Kodama D, Saito M, Matsumoto W, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2004,第1a2期

机译：基质金属蛋白酶9（MMP-9）基因启动子中较长的二核苷酸重复多态性与较高的HTLV-I相关税收介导的转录活性影响与HTLV-1相关的脊髓病/热带痉挛性轻瘫（HA）的风险
4. Autoimmune Chronic inflammatory Arthropathy in Mice Transgenic For the Htlv-i Tax Gene [C] . Yoichiro Iwakura Japanese Cancer Association . 2003

机译：HTLV-I税基因小鼠转基因的自身免疫性慢性炎症关节病
5. Regulation of HTLV-I oncoprotein Tax by PDLIM2. [D] . Yan, Pengrong. 2010

机译：通过PDLIM2调节HTLV-1癌蛋白税。
6. Transcriptional Activity of HTLV-I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation [O] . Francene J. Lemoine, Diane R. Wycuff, Susan J. Marriott 2001

机译：HTLV-I税收的转录活性影响与细胞转化相关的标记基因的表达。
7. Life, death and Tax: role of HTLV-I oncoprotein in genetic instability and cellular transformation [O] . JEANG K.T., GIAM C., MAJONE F., 2004

机译：生命，死亡和税收：HTLV-1癌蛋白在遗传不稳定和细胞转化中的作用

Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

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