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首页> 外文期刊>Sao Paulo Medical Journal >Mammary adenectomy followed by immediate reconstruction for treatment of patients with early-infiltrating breast carcinoma: a cohort study
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Mammary adenectomy followed by immediate reconstruction for treatment of patients with early-infiltrating breast carcinoma: a cohort study

机译：乳腺腺切除术后，立即重建治疗早期浸润乳腺癌的患者：队列研究

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BACKGROUND: Use of mammary adenectomy for breast carcinoma treatment remains controversial. OBJECTIVE: This study aimed to verify the oncological safety of mammary adenectomy and immediate breast reconstruction for treating selected patients with infiltrating breast carcinoma and to evaluate patients’ satisfaction with the reconstructed breasts. DESIGN AND SETTING: Cohort study conducted among patients treated at Hospital Sírio-Libanês, S?o Paulo, Brazil. METHODS: This study was based on 152 selected patients (161 operated breasts) with infiltrating breast carcinoma who underwent mammary adenectomy and immediate breast reconstruction. In all patients, the diameter of the largest focus of the tumor was less than 3.0 cm, the imaging tumor-nipple distance was greater than 2.0 cm and the pathological assessment showed clear margins. The cumulative incidence of local recurrence (LR), recurrence-free survival (RFS) and overall survival (OS) curves were estimated using the Kaplan-Meier method. After at least one year of follow-up, 64 patients were asked about their satisfaction with the reconstructed breast(s). RESULTS: At a mean follow-up time of 43.5 months, seven cases of LR (4.4%), four distant metastases (2.6%) and five deaths (3.3%) were recorded. The five-year actuarial LR-free survival, RFS and OS were 97.6%, 98.3% and 98.3%, respectively. No cases of nipple-areolar complex recurrence were reported. Forty-one patients (64%) indicated a high level of satisfaction with the reconstructed breasts. CONCLUSIONS: Mammary adenectomy is a safe and efficacious procedure for selected patients with early-infiltrating breast carcinoma and results in a high rate of patient satisfaction with the reconstructed breasts.
机译：背景：使用乳腺癌患者乳腺癌治疗仍存在争议。目的：本研究旨在验证乳腺腺切除术和立即乳腺重建的肿瘤治疗，用于治疗浸润乳腺癌的选定患者，评价患者对重建乳房的满意度。设计与环境：群组在医院Sírio-libanês，s？o Paulo，巴西治疗的患者中进行。方法：本研究基于152名选定的患者（161次操作的乳房），渗透乳腺癌接受乳腺癌和立即乳腺重建。在所有患者中，肿瘤的最大焦点的直径小于3.0厘米，成像肿瘤 - 乳头距离大于2.0cm，病理评估显示出透明的边缘。使用Kaplan-Meier方法估计局部复发（LR），无复发存活（RFS）和总存活（OS）曲线的累积发生率。在至少一年的后续后，64名患者被问及他们对重建的乳房的满意度。结果：在43.5个月的平均随访时间，记录了7例LR（4.4％），四个远距离转移（2.6％）和五次死亡（3.3％）。为期五年的致剂LR-FRES存活，RFS和OS分别为97.6％，98.3％和98.3％。没有报告Nipple-ansolar复杂复发情况。四十一名患者（64％）表明与重建的乳房的满意度高。结论：乳腺腺肿切除术是针对早期渗透乳腺癌的患者的安全和有效的程序，并导致高患者与重建的乳房的满意度。

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