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首页> 外文期刊>Sao Paulo Medical Journal >Amount of physical activity necessary for a normal level of high-sensitivity C-reactive protein in ELSA-Brasil: a cross-sectional study
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Amount of physical activity necessary for a normal level of high-sensitivity C-reactive protein in ELSA-Brasil: a cross-sectional study

机译：ELSA-BRASIL中正常高敏感性C-反应蛋白质所需的身体活性量：横截面研究

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BACKGROUND: Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation. OBJECTIVE: To identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults. DESIGN AND SETTING: Cross-sectional study at six teaching and research institutions. METHODS: The study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP ( 3 mg/l). RESULTS: The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex. CONCLUSIONS: Physical activity in the leisure-time and commuting domains together, of duration 200 minutes/week, was associated with normal hs-CRP values.
机译：背景：研究表明，物理活性水平可以与高敏感性C反应蛋白（HS-CRP）水平反向相关。然而，维持正常HS-CRP水平所需的身体活动量仍然是猜测的问题。目的：确定区分成人HS-CRP水平所需的身体活动量。设计与环境：六个教学研究机构的横断面研究。方法：研究样本包含10,231名成人35至74岁的成年人参与者对成人健康（Elsa-Brasil）的纵向研究。构建接收器操作特征（ROC）曲线以比较两个域（休闲时间和通勤）的身体活动量，HS-CRP水平。计算敏感性和特异性以鉴定保持正常水平的HS-CRP（<3mg / L）所需的身体活性水平的最佳截止。结果：ROC曲线下的面积仅在将两项研究结构域加入时根据物理活动量鉴别正常水平的HS-CRP。累计的身体活动水平为200分钟/周是最佳截止，用于区分两性的成年人的HS-CRP的正常水平。结论：休闲时间和通勤域的身体活动在200分钟/周的持续时间，与正常的HS-CRP值相关联。

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