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首页> 外文期刊>Sage Open Medicine >Prevalence of human T-lymphotropic virus 1/2 in Nigeria’s capital territory and meta-analysis of Nigerian studies
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Prevalence of human T-lymphotropic virus 1/2 in Nigeria’s capital territory and meta-analysis of Nigerian studies

机译：尼日利亚资本领土1/2人体T型龙眼病毒的患病率及尼日利亚研究的荟萃分析

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Objectives: This study was aimed at determining human T-lymphotropic virus 1/2 prevalence among apparently healthy, immunocompromised and haematologic malignant individuals in Nigeria’s capital, as well as meta-analysis of all Nigerian studies until date. Methods: A total of 200 participants were recruited into a cross-sectional study. In total, 1?mL each of sera and plasma were obtained from 5?mL blood of each participant and analysed for antibodies to human T-lymphotropic virus 1/2 using enzyme-linked immunosorbent assay; positive samples confirmed with qualitative real-time polymerase chain reaction, followed by statistical and meta-analysis. Sociodemographic characteristics and possible risk factors were assessed via questionnaires. Results: Enzyme-linked immunosorbent assay yielded 1% prevalence which was confirmed to be zero via polymerase chain reaction. A total of 119 (59.5%) of the participants were male, while the mean age was 35.28?±?13.61?years. Apart from sex and blood reception/donation, there was generally a low rate of exposure to human T-lymphotropic virus–associated risk factors. Meta-analysis revealed pooled prevalence of human T-lymphotropic virus 1 and 2 to be 3% and 0%, respectively, from Nigerian studies. Conclusion: This study discovered zero prevalence of human T-lymphotropic virus 1/2 from five major hospitals in Nigeria’s capital, exposing the importance of confirmatory assays after positive antibody detection assay results. Meta-analysis highlighted the existence of very few reliable Nigerian studies compared to the demography of the nation. Large-scale epidemiological studies and routine screening of risk populations are therefore needed since Nigeria lies in the region of endemicity.
机译：目的：本研究旨在确定尼日利亚资本中明显健康，免疫功能性和血吸虫学个人的人T-onMphotopic病毒1/2流行，以及所有尼日利亚研究的荟萃分析到达日期。方法：招募了200名参与者的横断面研究。总共1？ml每种参与者的5μl血液中的每种血清和血浆获得，并使用酶联免疫吸附测定分析对人T型射频病毒1/2的抗体;用定性实时聚合酶链反应证实阳性样品，其次是统计和荟萃分析。通过问卷评估社会渗目特征和可能的风险因素。结果：酶联免疫吸附试验产生1％的流行率，其证实通过聚合酶链反应为零。共有119名（59.5％）的参与者是男性，而平均年龄为35.28？±13.61岁。除了性和血液接收/捐赠之外，通常对人T型淋巴细胞病毒相关危险因素的暴露率通常是低的。荟萃分析显示人T-inmphotropic病毒1和2的汇总率分别来自尼日利亚研究的3％和0％。结论：本研究发现尼日利亚首都五大医院人体T型龙眼病毒1/2患病率为1/2，暴露阳性抗体检测试验结果后确认测定的重要性。荟萃分析突出了与国家人口统计相比非常少数可靠的尼日利亚研究的存在。因此，自尼日利亚在流行的区域中，因此需要大规模流行病学研究和常规筛查风险群体。

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