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外文期刊>Saudi Journal of Anaesthesia
>What is the exact predictive role of preoperative white blood cell count for new-onset atrial fibrillation following open heart surgery?
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What is the exact predictive role of preoperative white blood cell count for new-onset atrial fibrillation following open heart surgery?
Background: Atrial fibrillation (AF) occurs in 30% patients on the second or third day post operation; therefore, it is the most prevalent and complicated arrhythmia after open heart surgery. White blood cell (WBC) count seems to be most significantly associated with cardiovascular disorders. This study was designed to evaluate the exact relationship between preoperative WBC count and post-Coronary artery bypass graft (CABG) AF in patients with severe left ventricle (LV) dysfunction who underwent elective off-pump coronary artery bypass. Methods: This study was conducted on 104 patients from among 400 patients with severe LV dysfunction undergoing elective off-pump CABG surgery from February 2011 to February 2012, in Afshar Cardiovascular Center, Yazd, Iran. Patients with emergency surgery, unstable angina creatinine higher than 2.0 mg/dL, malignancy, or immunosuppressive disease were excluded. Preoperative serological tests of the participants, such as WBC counts, were saved in their medical dossiers. Of the 400 patients undergoing CABG, AF was found in 54 cases; these 54 male patients formed the experimental group and 60 other patients in the intensive care unit (ICU) and hospital stay without postoperative AF were part of the control group. Results: The average age of the patients was 68.5±12.8 years. WBC counts in patients with and without AF three days before surgery were 12,340±155 and 8,950±170, respectively. On surgical day, WBC counts in the patients with and without AF were 13,188±140 and 9,145±255, respectively ( P value three days before surgery: 0.04; P value on surgical day: 0.01). Of the 54 male patients with postoperative AF (POAF), duration of AF was more in cases with elevated WBC count (12,000-14,000) than in those with lower elevated WBC count (10,000-12,000) (] P =0.025), but there was no relationship between frequency of recurrence of AF and grading of elevation of WBC count (] P =0.81). Conclusion: These findings show that three days before surgery and on surgery day, there was a difference in WBC count between both groups. So, preoperative WBC count may predict the incidence and duration of AF; however, it cannot be a predictor of the frequency of recurrence of AF. Finally, WBC count is an independent marker for POAF and duration of AF.
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机译：背景：心房颤动（AF）发生在30％患者的第二天或第三天的术后30％;因此，在开放心脏手术后，它是最普遍和复杂的心律失常。白细胞（WBC）计数似乎与心血管障碍最显着相关。该研究旨在评估术前WBC计数和冠状动脉后术后术后患者的确切关系，在患有主要的左心室（LV）功能障碍的患者中接受选修型冠状动脉旁路。方法：本研究于2011年2月至2012年2月，在2012年2月至2012年2月，在2012年2月至2012年2月，在2012年至2012年2月，在Afshar Cardovular Center，Yazd，Irazd，伊朗，在400名患者中进行了400名患者。患者应急手术，不稳定的心绞痛肌酐高于2.0mg / dl，恶性肿瘤或免疫抑制疾病。参与者的术前血清学检测，例如WBC计数，在其医疗档案中保存。在接受CABG的400名患者中，AF发现于54例;这54名男性患者形成了实验组和60名其他患者在重症监护病房（ICU）和医院住宿，没有术后AF是对照组的一部分。结果：患者的平均年龄为68.5±12.8岁。手术前三天的患者患有AG 2,340±155和8,950±170的患者。在手术日，患有和无AF的患者的WBC计数分别为13,188±140和9,145±255（手术前三天：0.04; P值在手术日：0.01）。在54名患有术后AF（POAF）的男性患者中，WBC升高（12,000-14,000）升高的情况下，AF的持续时间更多，而不是较低的WBC计数（10,000-12,000）（] P = 0.025），但在那里AF复发频率与WBC计数升高的分级（] P = 0.81）之间没有任何关系。结论：这些研究结果表明，手术前三天和手术日，两组之间的WBC计数差异。因此，术前WBC计数可能预测AF的发病率和持续时间;然而，它不能是AF的复发频率的预测因子。最后，WBC计数是POAF和AF的持续时间的独立标记。
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