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首页> 外文期刊>Saudi Journal of Anaesthesia >Low-dose ketamine infusion for labor analgesia: A double-blind, randomized, placebo controlled clinical trial
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Low-dose ketamine infusion for labor analgesia: A double-blind, randomized, placebo controlled clinical trial

机译：低剂量氯胺酮输注用于分娩镇痛：双盲，随机，安慰剂受控临床试验

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Background: Most primary and secondary level hospitals in developing countries provide inadequate labor analgesia due to various medical, technical and economic reasons. This clinical trial was an effort to study the efficacy, safety and feasibility of intravenous (IV) ketamine to provide labor analgesia. Materials and Methods: A total of 70 parturients were consented and randomly assigned to receive either IV ketamine or 0.9% saline. A loading dose of ketamine (0.2 mg/kg) was followed-by an infusion (0.2 mg/kg/h) until the delivery of the neonate. Similar volume of saline was infused in the placebo-group. Intramuscular meperidine was the rescue analgesic in both groups. The pain score, hemodynamic parameters of mother and fetus and the anticipated side-effects of ketamine were observed for. The newborn was assessed by the Neonatologist. Results: The pain score showed a decreasing trend in the ketamine group and after the 1st h more than 60% of women in the ketamine group had pain relief, which was statistically significant. There was no significant clinical change in the maternal hemodynamics and fetal heart rate. However, 17 (48.5%) of them had transient light headedness in the ketamine group. All the neonates were breast fed and the umbilical cord blood pH was between 7.1 and 7.2. The overall satisfaction was significantly high in the intervention group ( P = 0.028). Conclusion: A low-dose ketamine infusion (loading dose of 0.2 mg/kg delivered over 30 min, followed-by an infusion at 0.2 mg/kg/h) could provide acceptable analgesia during labor and delivery.
机译：背景：发展中国家的大多数中小级医院由于各种医疗，技术和经济原因，劳动力镇痛不足。该临床试验是努力研究静脉注射（IV）氯胺酮提供分娩镇痛的疗效，安全性和可行性。材料和方法：共同同意70种份额，随机分配给接收静脉酮酮或0.9％盐水。将氯胺酮（0.2mg / kg）的装载剂量进行，然后输注（0.2mg / kg / h）直至递送新生酸盐。相似体积的盐水注入安慰剂组。肌内哌替啶是两组中的抢救镇痛。观察到疼痛评分，母亲和胎儿的血流动力学参数以及氯胺酮预期的副作用。新生儿被新生儿学家评估。结果：疼痛评分显示氯胺酮组的趋势降低，在氯胺酮组中超过60％的女性患有疼痛缓解，致致统计学意义。母体血流动力学和胎儿心率没有显着的临床变化。然而，其中17个（48.5％）在氯胺酮组中具有瞬态光线头。所有的新生儿都是乳房喂养，脐带血pH值在7.1到7.2之间。干预组总体满意度显着高（P = 0.028）。结论：低剂量氯胺酮输注（在30分钟内输送0.2mg / kg的加载剂量，随后输注0.2mg / kg / h）可在劳动和递送期间提供可接受的镇痛。

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