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首页> 外文期刊>Southern African journal of HIV medicine >Measles in adults: A comparison of hospitalised HIV-infected and HIV-uninfected patients
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Measles in adults: A comparison of hospitalised HIV-infected and HIV-uninfected patients

机译：成人麻疹：住院病艾滋病毒感染和艾滋病毒无感染患者的比较

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Background: Although measles is traditionally a childhood illness, there are an increasing number of adult cases. Despite both measles and HIV infection being endemic in sub-Saharan Africa, there are little data regarding outcomes in co-infected patients.Objectives: Compare demographic, clinical, laboratory and radiographic features, as well as outcome (length of hospital stay, complications and mortality) between HIV-infected and HIV-uninfected adult patients admitted with confirmed measles.Methods: We conducted a retrospective record review of adult patients with confirmed measles who were admitted to the Infectious Diseases Unit at the Charlotte Maxeke Johannesburg Academic Hospital during the peak of the 2009 and 2010 South African measles outbreak. The data collected included demographic, clinical and laboratory parameters, as well as outcomes.Results: Of the 33 confirmed measles cases admitted, 24 patients were tested for HIV infection and 18 tested seropositive. There were no significant differences in the demographics, clinical findings or laboratory data when comparing the HIV-positive and HIV-negative cases. Serious clinical manifestations were seen more frequently in HIV-positive patients (odds ratio [OR] 5, 95% confidence interval [CI] 0.48–51.8, p = 0.34). One of the six patients testing HIV-negative developed pneumonia, while six of the 18 HIV-positive patients had a course complicated by pneumonia. Five of these HIV-positive patients required admission to the intensive care unit, three developing respiratory failure necessitating mechanical ventilation. HIV-positive patients had several other manifestations, including acute kidney injury, purulent conjunctivitis, pancreatitis and encephalitis. HIV-positive patients had a significantly longer hospital stay (p = 0.03). There were three deaths in the HIV-positive group, but none in the HIV-negative group (OR 2.9, 95% CI 0.13–65.3, p = 0.55).Conclusion: Our study provides data on the largest series of hospitalised adults infected with HIV and co-infected with measles. More severe consequences seemed to occur in hospitalised HIV-positive patients.
机译：背景：虽然麻疹传统上是童年的疾病，但成年病例数量越来越多。尽管麻疹和艾滋病毒感染是撒哈拉以南非洲的流行，但在有关患者中有几乎没有关于结果的数据。目的：比较人口，临床，实验室和放射线特征，以及结果（住院住院的长度，并发症和艾滋病毒感染和艾滋病毒无感染的成年患者之间的死亡率。方法：我们对成年患者进行了回顾性记录，确认麻疹患者在夏洛特Maxeke Johannesburg学术医院的夏洛特峰值期间被录取2009年和2010年南非麻疹爆发。收集的数据包括人口统计，临床和实验室参数，以及结果。结果：33例确诊麻疹病例，24例患者进行HIV感染和18个测试的血清阳性。在比较艾滋病毒阳性和HIV阴性病例时，人口统计学，临床发现或实验室数据没有显着差异。在艾滋病毒阳性患者中更频繁地看到严重的临床表现（差距[或] 5,95％置信区间[CI] 0.48-51.8，P = 0.34）。六名患者中的六个患者之一，艾滋病毒阴性发育肺炎，而18例艾滋病毒阳性患者中有六个受肺炎复杂化的课程。这些艾滋病毒阳性患者中的五种必需的患者进入重症监护病房，三种发展呼吸衰竭需要机械通气。艾滋病毒阳性患者有几种其他表现形式，包括急性肾损伤，脓性结膜炎，胰腺炎和脑炎。艾滋病毒阳性患者的住院时间明显更长（P = 0.03）。艾滋病毒阳性群体中有三种死亡，但无HIV阴性组（或2.9,95％CI 0.13-65.3，P = 0.55）。结论：我们的研究提供了有关感染的最大系列住院成人系列的数据艾滋病毒并共同感染麻疹。住院患者的艾滋病毒阳性患者似乎发生了更严重的后果。

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