...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Stem cells international >Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools
【24h】

Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools

机译：根据当前专家的建议，在肌营养的外壳中血管术后硬化中的脂肪移植治疗中的肿瘤组织衍生细胞：选择最佳监测工具

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes. Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts. They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set. Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality of transplanted cells and to correlate ADRC properties with clinical outcome.
机译：干细胞（SCS）可以构成神经变性疾病中药理学治疗的透视替代方案。虽然SC移植的安全性已被广泛显示，但它们仍然证明其在肌萎缩侧面硬化症（ALS）中的临床效率。它不仅是由于有限数量的研究，小治疗组和快速但非线性疾病进展，而且由于缺乏能够显示微妙的临床变化的客观方法。一组ALS专家提出了细胞疗法的初步准则。它们将临床，神经生理学和功能评估与对细胞因子水平的监测相结合。在这里，我们描述了一种关于将自体脂肪衍生的再生细胞（ADRC）移植到患者患者脊髓脊髓的试验研究，并根据当前建议监测结果。为了在感兴趣的肌肉内显示早期和/或微妙的变化，使用各种临床和功能测试，并比较，以选择最敏感和最佳的集合。另外，提供了对移植的ADRC的分析，以制定标准的标准，确保衍生和验证移植细胞的足够质量，并将ADRC性质与临床结果相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号