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首页> 外文期刊>Systematic Reviews >Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials
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Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials

机译：代谢综合征患者血液葡萄糖，血脂血症，血压和腹部肥胖对禁食葡萄糖，血脂血症，腹部肥胖的影响：随机对照试验的系统审查和荟萃分析的议定书

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Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I2-heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting.
机译：维生素D缺乏可以在涉及与代谢综合征（METS）相关的一组风险因素的替代季度功能中发挥作用。本综述的目的是探讨维生素D补充对患有MET患者患者腹腔葡萄糖，血脂血症，血压和腹部肥胖的影响。 Embase，Medline，Science，Lilacs，Cochrane中央登记，Cochrane中央登记，Clincoicaltrials.gov数据库和灰色文献将被系统地搜索维生素D补充的随机对照试验（RCT），与安慰剂相比，到2020年12月。我们将包括在研究患者中诊断出由国家胆固醇教育计划成人处理小组III或国际糖尿病联合会所提出的标准诊断的。口服维生素D补充对脂质曲线改善（甘油三酯，高密度脂蛋白胆固醇-HDL-C）的影响是本综述的主要结果。系统审查将在系统评价和荟萃分析（PRISMA）指南的首选报告项目后进行。根据偏置工具的Cochrane风险（Rob 2.0），两个独立审阅者将由两个独立审阅者履行研究筛选，数据提取和质量评估。系统审查的结果将根据干预的类型，目标群体的特征，维生素D的测量方法，计算的维生素D浓度，生物样品类型以及结果的类型。荟萃分析将在适当的情况下进行。 Cochran的Q测试和I2异质性试验将用于评估异质性的存在，以及固定的或随机效应模型是否适合使用反方差方法或倾司 - 丽脂方法组合研究结果。将使用漏斗图和EGGER和BEGG测试进行评估出版物偏见。证据的实力将根据建议评估，发展和评估（等级）的评分进行评估。这种系统审查将评估维生素D补充对空腹葡萄糖和甘油三酯水平，腰围和平均血压的影响，以及具有MET的个体中的HDL-C。这些调查结果可以帮助在临床环境中决策。

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