Optogenetic approach allows controlling morphological parameters of dendritic spines in cortico-striatal co-culture

Artamonov Dmitry N.; Korzhova Victoria V.; Vlasova Olga L.; Bezprozvanny Ilya B.

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Optogenetic approach allows controlling morphological parameters of dendritic spines in cortico-striatal co-culture

机译：致光学方法允许控制皮质纹纹合培养中树突刺的形态参数

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Optogenetics is a unique technique that allows controlling the physiological condition within single cellor specific cell population, including controlling individual neuron activity. In the present work optogenetics has been applied to control the morphology and density of synaptic connections between striatal and cortical neurons in mixed cortico-striatal co-culture system. Different methods for visualization of medium spiny neurons dendritic spines have been compared. Studying synaptic dysfunction is necessary for understanding both normal physiology of brain and pathological mechanisms in different neurodegenerative diseases. The described approach could be utilized in a numerous biomedical applications.

机译：Optogenetics是一种独特的技术，允许控制单型细胞特异性细胞群内的生理状况，包括控制个体神经元活性。在本作的工作中，已经应用光学学，用于控制混合皮质纹纹综合培养系统中纹状体和皮质神经元之间突触连接的形态和密度。已经比较了用于中等刺神经元树突刺的不同方法。研究突触功能障碍是理解不同神经变性疾病中脑和病理机制的正常生理所必需的。所描述的方法可以在许多生物医学应用中使用。

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《St. Petersburg Polytechnic University Journal: Physics and Mathematics》 |2013年第4期|共10页
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Artamonov Dmitry N.; Korzhova Victoria V.; Vlasova Olga L.; Bezprozvanny Ilya B.;
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optogeneticsdendritic spinessynaptic transmissionneuronal culture;

机译：Optogentics树突刺突触传递神经元培养;

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1. The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation. [J] . Haeckel A, Ahuja R, Gundelfinger ED, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2008,第40期

机译：肌动蛋白结合蛋白Abp1控制树突状脊柱的形态，对脊柱头部和突触形成很重要。
2. Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex [J] . Sulistomo Hikmawan Wahyu, Nemoto Takayuki, Kage Yohko, Cerebral cortex . 2021,第4期

机译：FHOD3控制小鼠脑皮层中金字塔神经元特异性群体的树突状脊柱形态
3. Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines [J] . Koester Jan-Dietrich, Leggewie Birthe, Blechner Christine, Cellular Signalling . 2016,第1期

机译：肌醇-1,4,5-三磷酸-3-激酶-A控制海马树突棘的形态
4. Dendritic locations and dendritic spine morphology determine effectiveness of thalamocortical pathways in the auditory cortex [C] . Richardson R.J., Blundon J.A., Bayazitov I.T., Biomedical Science amp; Engineering Conference, 2009. BSEC 2009 . 2009

机译：树突位置和树突棘形态决定了听觉皮层丘脑皮质通路的有效性
5. Age-related morphologic alterations in the brain of macaque monkey: Dendritic morphology, spine density, and catecholaminergic innervation. [D] . Duan, Huiling. 2003

机译：猕猴大脑中与年龄相关的形态变化：树突形态，脊柱密度和儿茶酚胺能神经支配。
6. Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression [O] . Patrik Hollos, Jismi M. John, Jukka V. Lehtonen, 2020

机译：脊柱头JNK的光遗传学控制揭示了树突状脊柱退化的作用。
7. The Actin-Binding Protein Abp1 Controls Dendritic Spine Morphology and Is Important for Spine Head and Synapse Formation [O] . A. Haeckel, R. Ahuja, E. D. Gundelfinger, 2008

机译：肌动蛋白结合蛋白ABP1控制树突脊柱形态，对脊柱头和突触形成很重要

Optogenetic approach allows controlling morphological parameters of dendritic spines in cortico-striatal co-culture

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