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首页> 外文期刊>Pakistan journal of nutrition: PJN >The Effects of Replacement of Dietary Fiber with FiberCremesup?/sup on Lowering Serum Glucose and Improvement of Lipid Profile in Hypercholesterolemia-Diabetic Rats and Its Mechanism
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The Effects of Replacement of Dietary Fiber with FiberCremesup?/sup on Lowering Serum Glucose and Improvement of Lipid Profile in Hypercholesterolemia-Diabetic Rats and Its Mechanism

机译：用纤维蠕动β在高胆固醇血症 - 糖尿病大鼠中降低血清葡萄糖和脂质曲线的改善的影响及其机制

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Background and Objectives: Dietary fiber is an important component in the diet and has important effects on health, such as reducing plasma glucose and cholesterol levels. FiberCremesup?/sup is a commercial nondairy creamer that uses a variety of oligosaccharides as a source of fiber to replace the glucose component of conventional creamer combined with healthy oils as a palatable functional ingredient .The objectives of this study were to determine the effects of the replacement of dietary fiber with FiberCremesup?/sup on lowering glucose and improvement of the lipid profile of hypercholesterolemia- diabetic rats . The possible mechanism of lowering cholesterol and glucose level was also studied in vitro . Materials and Methods: The diets used included a standard diet and a FiberCremesup?/sup diet. Standard diets were fed to the rats in the control-healthy (CH), control-diabetic (CD) and metformin (METF) groups. FiberCremesup?/sup diets were given to rats in the FC50, FC100 and FC150 groups. Results: The results showed that the FC100 diet decreased glucose by 56%, which is similar to the decrease seen with metformin (59%). The FC100 diet also reduced total cholesterol, LDL cholesterol and triglycerides by 84.2 mg dLsup?1/sup (46%), 31.69 mg dLsup?1/sup (43%), 18.9 mg dLsup?1/sup (15%), respectively and increased the HDL level from 24.1-50.2 mg dLsup?1/sup (108%). Conclusion: The in vitro study indicated that one of the mechanisms of lowering glucose was through the inhibition of glucose absorption in the small intestine and the mechanism of lowering cholesterol was through bile acid binding to the FiberCremesup?/sup.
机译：背景和目标：膳食纤维是饮食中的重要组成部分，对健康有重要影响，例如还原血浆葡萄糖和胆固醇水平。 Firecercreme ？是一种商业鼻制奶精，其使用各种低聚糖作为纤维来源，以替代常规奶精的葡萄糖组分与健康的油脂作为可口的官能成分。本研究的目的是确定膳食纤维与纤维纤维β-β-更换的效果降低葡萄糖和改善高胆固醇血症大鼠的脂质谱。还研究了在体外降低胆固醇和葡萄糖水平的可能机制。材料和方法：使用的饮食包括标准饮食和纤维蠕变 _ / sup>饮食。将标准饮食送入对照 - 健康（CH），对照 - 糖尿病（CD）和二甲双胍（MetF）组中的大鼠中。 Fibercreme β-饮食给FC50，FC100和FC150组中的大鼠。结果：结果表明，FC100饮食葡萄糖减少了56％，这与二甲双胍（59％）相似。 FC100饮食还将总胆固醇，LDL胆固醇和甘油三酯降低了84.2mg DL 1 -1 / sop>（46％），31.69mg dl 1///p>（43％），18.9mg dl 1 / sup>（15％）分别从24.1-50.2mg dl 1（108％）增加了HDL水平。结论：体外研究表明，降低葡萄糖的一种机制是通过抑制小肠中的葡萄糖吸收，降低胆固醇的机制通过胆汁酸结合到纤维探测器 。

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