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首页> 外文期刊>Patient Preference and Adherence >Fixed Versus Free Combinations Of Antihypertensive Drugs: Analyses Of Real-World Data Of Persistence With Therapy In Italy
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Fixed Versus Free Combinations Of Antihypertensive Drugs: Analyses Of Real-World Data Of Persistence With Therapy In Italy

机译：修复了抗高血压药物的免费组合：在意大利治疗持久性的实际数据分析

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Purpose: To analyse the pattern of use and cost of antihypertensive drugs in new users in an Italian population, and explore the patient/treatment factors associated with the risk of therapy discontinuation. Patients and methods: In this retrospective study, information was collected from a population-based electronic primary-care database. Persistence with medication use 1 year from therapy initiation was evaluated for each user using the gap method. Each new user was classified according to his/her pattern of use as: “continuer”, “discontinuer” “switching” or “add-on”. A Cox regression model was used to analyse the factors influencing therapy discontinuation. Primary-care costs comprised specialists’ visits, diagnostic procedures and pharmacologic therapies. Results: Among 14,999 subjects included in persistence analyses, 55.1% of cases initially started on monotherapy were classified as discontinuers vs 36.5% of cases taking combination therapy (42.3% vs 32.7%, respectively, for free and fixed combinations, P 0.01). Old age, high cardiovascular risk and being in receipt of fixed-combination therapy were associated with greater persistence. Overall, the primary-care cost/person/year of hypertension management was ～€95.3 (IQR, 144.9). The monotherapy cost was €88 per patient (IQR, 132.9), and that for combination therapy was €151±148.3. The median cost/patient with a fixed combination was lower than that for a free combination (€98.4 (IQR, 155.3) and €154.9 (IQR, 182.6), respectively). Conclusion: The initial type of therapy prescribed influences persistence. Prescribing fixed combinations might be a good choice as initial therapy.
机译：目的：分析意大利人口新用户的使用和成本的使用和成本，并探讨与疗法停止的风险相关的患者/治疗因素。患者和方法：在此回顾性研究中，从基于人口的电子初级保养数据库收集信息。使用GAP方法对每个用户评估治疗开始的药物使用1年的持久性。每个新用户根据他/她的用途分类为：“连续人”，“indontinuer”“切换”或“加载项”。 COX回归模型用于分析影响治疗停药的因素。初级保养成本包括专家访问，诊断程序和药理学疗法。结果：持久性分析中包含的14,999个受试者中，55.1％的案件最初开始于单药治疗的病例被归类为停止intinuers与36.5％的案例分别进行组合治疗（分别为32.7％，分别为免费和固定组合，P <0.01）。年龄较大，高心血管风险和接收到固定联合治疗的持久性与更大的持久性有关。总体而言，高血压管理的初级保育费用/人/年度〜95.3欧元（IQR，144.9）。每位患者的单一疗法成本为88欧元（IQR，132.9），而且组合治疗的额为151±148.3欧元。固定组合的中位数/患者分别低于自由组合（98.4欧元（IQR，155.3）和154.9欧元（IQR，182.6欧元）的成本/患者。结论：规定的初始治疗类型影响持久性。规定的固定组合可能是初始治疗的良好选择。

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