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首页> 外文期刊>Parasite Epidemiology and Control >Clinical, serological and DNA testing in Bengo Province, Angola further reveals low filarial endemicity and opportunities for disease elimination
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Clinical, serological and DNA testing in Bengo Province, Angola further reveals low filarial endemicity and opportunities for disease elimination

机译：安哥拉在孟乐省临床，血清学和DNA检测进一步揭示了低偏心性和疾病消除的机会

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The prevalence ofLoa loa, Onchocerca volvulusandWuchereria bancroftiinfections in an under-surveyed area of Bengo Province, Angola, was determined by surveying 22 communities with a combination of clinical, serological and DNA diagnostics. Additional information was collected on participants' duration of residency, access to mass drug administration, knowledge of insect vectors and use of bednets. A total of 1616 individuals (38.1% male: 61.9% female), with an average age of 43?years, were examined. For L.loa,6.2% (n?=?100/16616) individuals were found to have eyeworm, based on the rapid assessment procedure for loiasis (RAPLOA) surveys, and 11.5% (n?=178/1543) based on nested PCR analyses of venous blood.L. loaprevalences in long-term residents (>10?years) and older individuals (>60?years) were significantly higher, and older men with eyeworm were better informed aboutChrysopsvectors. ForO. volvulus, 4.7% (n?=?74/1567) individuals were found to be positive by enzyme-linked immunosorbent assay (Ov 16 ELISA), with only three individuals reporting to have ever taken ivermectin. ForW. bancrofti,no infections were found using the antigen-based immunochromatographic test (ICT) and real-time PCR analysis; however, 27 individuals presented with lymphatic filariasis (LF) related clinical conditions (lymphoedema?=?11, hydrocoele?=?14, both?=?2). Just under half (45.5%) of the participants owned a bednet, with the majority (71.1%) sleeping under it the night before. Our approach of using combination diagnostics reveals the age-prevalence of loiasis alongside low endemicity of onchocerciasis and LF. Future research foci should be on identifying opportunities for more cost-effective ways to eliminate onchocerciasis and to develop innovative surveillance modalities for clinical LF for individual disease management and disability prevention.
机译：在安哥拉孟戈省孟戈省下受访地区的Onchocerca volvulusandwuchereria bancroftiinfections的患病率是通过调查22个社区的临床，血清学和DNA诊断。在参与者的居住持续时间内收集了更多信息，获得大规模药物管理局，昆虫载体知识和使用蚊帐。共有1616名（38.1％男性：61.9％），平均年龄为43岁以下的人，审查了40岁。对于L.LOA，有6.2％（n？= 100/16616），基于嵌套的荷载（raploa）调查的快速评估程序，基于快速评估程序，基于快速评估程序，基于嵌套的11.5％（n？= 178/1543），有6.2％（n？= 100/16616）个体。 PCR分析静脉血液。长期居民（> 10？年）和老年人（> 60岁）的LoopRevalences显着更高，更好地了解了眼镜的老年人。 foro。 Volvulus，4.7％（N？= 74/1567）个体被酶联免疫吸附试验（OV 16 ELISA）阳性，只有三个人报告才能捕获伊维菌素。福特。 Bancrofti使用抗原的免疫层析试验（ICT）和实时PCR分析没有发现感染。然而，27个患有淋巴丝体（LF）相关的临床病症（淋巴水肿？=Δ11，水电α= 14，两者？=？2）。只有下面的一半（45.5％）的参与者拥有一只蚊帐，其中大多数（71.1％）在之前睡觉了。我们使用组合诊断的方法揭示了持续的onchocerciaSis和LF的低流行性的血糖的年龄普及。未来的研究焦点应该识别出于更具成本效益的方法来消除OnchocerciaSis的机会，并为个体疾病管理和残疾预防开发临床LF的创新监测方式。

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