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首页> 外文期刊>Parasites Vectors >Lymphatic filariasis control in Tanga Region, Tanzania: status after eight rounds of mass drug administration
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Lymphatic filariasis control in Tanga Region, Tanzania: status after eight rounds of mass drug administration

机译：坦桑尼亚唐纳地区淋巴丝虫病控制：八轮大众药物管理局后的地位

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Background Lymphatic filariasis (LF) control started in Tanga Region of Tanzania in 2004, with annual ivermectin/albendazole mass drug administration (MDA). Since then, the current project has monitored the effect in communities and schools in rural areas of Tanga District. In 2013, after 8 rounds of MDA, spot check surveys were added in the other 7 districts of Tanga Region, to assess the regional LF status. Methods LF vector and transmission surveillance, and human cross sectional surveys in communities and schools, continued in Tanga District as previously reported. In each of the other 7 districts, 2?3 spot check sites were selected and about 200 schoolchildren were examined for circulating filarial antigens (CFA). At 1?2 of the sites in each district, additional about 200 community volunteers were examined for CFA and chronic LF disease, and the CFA positives were re-examined for microfilariae (mf). Results The downward trend in LF transmission and human infection previously reported for Tanga District continued, with prevalences after MDA 8 reaching 15.5% and 3.5% for CFA and mf in communities (decrease by 75.5% and 89.6% from baseline) and 2.3% for CFA in schoolchildren (decrease by 90.9% from baseline). Surprisingly, the prevalence of chronic LF morbidity after MDA 8 was less than half of baseline records. No infective vector mosquitoes were detected after MDA 7. Spot checks in the other districts after MDA 8 showed relatively high LF burdens in the coastal districts. LF burdens gradually decreased when moving to districts further inland and with higher altitudes. Conclusion LF was still widespread in many parts of Tanga Region after MDA 8, in particular in the coastal areas. This calls for intensified control, which should include increased MDA treatment coverage, strengthening of bed net usage, and more male focus in LF health information dissemination. The low LF burdens observed in some inland districts suggest that MDA in these could be stepped down to provide more resources for upscale of control in the coastal areas. Monitoring should continue to guide the programme to ensure that the current major achievements will ultimately lead to successful LF elimination.
机译：背景技术淋巴丝体（LF）控制于2004年在坦桑尼亚唐纳地区开始，每年伊维菌素/阿仑唑类药物施用（MDA）。从那时起，目前的项目已经监测了唐纳区农村社区和学校的效果。 2013年，经过8轮MDA，在唐纳地区的其他7区加入了现场检查调查，以评估区域LF状态。方法以前报道，在唐纳区继续在社区和学校的载体和传输监测和人类横断面调查中。在其他7区中的每一个中，选择了3个点检查部位，检查了大约200所学床，用于循环丝状抗原（CFA）。在每个地区的1？2位网站，为CFA和慢性LF疾病进行了额外的约200名社区志愿者，并重新检查了CFA阳性的阳性（MF）。结果唐娜区以前报道的LF传播和人类感染的下行趋势持续，普遍存在的普遍存在的普遍存在的CFA和CFA和MF在社区中的3.5％（从基线减少75.5％和89.6％）和2.3％在学龄儿童（从基线减少90.9％）。令人惊讶的是，MDA 8后慢性LF发病率的患病率不到基线记录的一半。在MDA 7后，在MDA 8在沿海地区显示相对较高的LF负担后，在其他地区发现了感染的蚊子。当进一步进入地区和更高的海拔地区时，LF负担逐渐减少。结论MDA 8在沿海地区的唐纳地区的许多部分仍然普遍存在唐纳地区。这项要求加强控制，这应包括增加的MDA治疗覆盖，加强床净用，以及更多男性重点在LF健康信息传播中。在某些内陆区观察到的低LF负担表明，这些中的MDA可以缩短，以便在沿海地区的升级控制更多的资源。监测应继续指导该方案，以确保目前的重大成就最终会导致淘汰取消成功。

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