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首页> 外文期刊>Pharmaceutics >Usefulness of Artificial Membrane, Strat-M ? , in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions
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Usefulness of Artificial Membrane, Strat-M ? , in the Assessment of Drug Permeation from Complex Vehicles in Finite Dose Conditions

机译：人造膜的有用性，Strat-m​​？ ，在有限剂量条件下评估复杂载体的药物渗透

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摘要

The ban on the use of animals in testing cosmetic products has led to the development of animal-free in vitro methods. Strat-M ? is an artificial membrane engineered to mimic human skin and is recommended as a replacement for skin. However, its usefulness in the assessment of the permeation of cosmetics in in-use conditions remains unverified. No data have been published on its comparative performance with the membrane of choice, porcine skin. The comparative permeability characteristics of Strat-M ? and porcine skin were investigated using Franz diffusion cells. Caffeine (CF) and rhododendrol (RD) in complex vehicles with varying concentrations of polyols were applied as finite and infinite doses. Good rank orders of permeation from finite dose experiments were observed for RD. High correlations were observed in RD permeation between Strat-M ? and porcine skin under finite and infinite dose conditions, whereas only finite dose conditions for CF were associated with good correlations. Permeation from formulations with high polyol content and residual formulations was enhanced due to the disruption of the integrity of the Strat-M ? barrier. The usefulness of Strat-M ? in the assessment of dermal permeation may be limited to finite dose conditions and not applicable to infinite dose conditions or formulations applied in layers.
机译：禁止在测试化妆品中使用动物的使用导致了无动物的体外方法的开发。 Strat-m​​？是一种用于模拟人体皮肤的人造膜，建议作为皮肤的替代品。然而，它在使用内使用条件中的化妆品渗透评估的其有用性仍未验证。没有通过选择的膜，猪皮的比较表现没有发表任何数据。 Strat-m​​的比较渗透特性？使用Franz扩散细胞研究了猪皮。将具有不同多元醇浓度的复合载体中的咖啡因（CF）和罗二代rol（RD）作为有限和无限剂量施加。观察到来自有限剂量实验的良好渗透序列进行RD。在Strat-M之间的RD渗透中观察到高相关？在有限和无限剂量条件下，猪皮和猪皮肤，而只有CF的有限剂量条件与良好的相关性有关。由于波纹-M的完整性的破坏，增强了具有高多元醇含量和残余制剂的制剂的渗透性掺杂？障碍。 Strat-m​​的有用性？在评估皮肤渗透的情况下，可以限于有限剂量条件，不适用于在层中施加的无限剂量条件或配方。

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