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首页> 外文期刊>Pharmacy Practice >The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled study
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The impact of pharmacist-led medication therapy management on medication adherence in patients with type 2 diabetes mellitus: a randomized controlled study

机译：药剂师LED药物治疗管理对2型糖尿病患者药物粘附的影响：随机对照研究

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Background: Poor adherence to antidiabetic medications leads to a higher rate of hospital admissions and adverse health outcomes in type 2 diabetes mellitus patients. Objective: This study aims to evaluate whether a pharmacist-led medication therapy management, compared to the usual care, could enhance medication adherence and reduce hospital admission in patients with type 2 diabetes mellitus. Methods: A prospective randomized controlled study was conducted in patients with type 2 diabetes mellitus from February 1 to July 30, 2016. Patients in the control group (n=65) received the usual care while patients in the intervention group (n=62) received a personalized pharmacotherapeutic care plan and diabetes education. The two groups were compared by repeated measure ANOVA at 3 and 6-months with medication adherence (using Morisky medication adherence scale) and number of hospital admissions as the main outcome variables. Results: A total of 127 patients were included in the study. A marked and statistically significant increase in medication adherence from baseline to 3 and 6 months were noted in the intervention group (increased from 9.2% at baseline to 61% at 6 month) compared with the control group (increased from 13.2% at baseline (to 30.2% at 6 month; p-value0.01). Furthermore, at the 6-month follow-up, only 23 patients in MTM group with poorly controlled blood glucose levels resulted in hospital admissions compared to 48 patients in non-MTM group, resulting in a 52.1% fewer hospital admissions (p 0.001). Conclusions: The findings of this study implied that pharmacist-led medication therapy management might improve medication adherence and reduce number of hospitalizations in patients with type 2 diabetes mellitus. Hence, policies and guidelines should be in place in order for clinical pharmacists to fully engage in patient care and improve the medication therapy outcomes.
机译：背景：对抗糖尿病药物的粘附不良导致2型糖尿病患者的医院入院率和不良健康结果。目的：本研究旨在评估药剂师LED药物治疗管理是否与通常的护理相比，可以增强药物依从性并减少2型糖尿病患者的医院入院。方法：2016年2月1日至7月30日患有2型糖尿病患者的预期随机对照研究。对照组（n = 65）的患者在干预组患者中获得了通常的护理（n = 62）收到了个性化的药物治疗计划和糖尿病教育。通过用药物粘附（使用Morisky药物粘附量表）和医院入学人数，通过重复测量Anova进行比较两组，以3和6个月的药物粘附（使用Morisky药物粘附量表）和作为主要结果变量的数量。结果：研究中共有127名患者。与对照组相比，在干预组中，在介入组（在6个月的3个月以31％增加到61％的9.2％，增加了3个和6个月的显着和统计学上显着增加。（从基线增加13.2％）（至6个月的30.2％; P值<0.01）。此外，在6个月的随访中，只有23名患者在MTM组中，血糖水平较低，导致医院入院与非MTM集团48名患者相比，导致较少的医院入学率为52.1％（P <0.001）。结论：本研究的结果暗示，药剂师LED药物治疗管理可能会改善药物依从性和减少2型糖尿病患者的住院次数。因此，政策和准则应该是为了使临床药剂师能够充分从事患者护理并改善药物治疗结果。

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