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首页> 外文期刊>Physical Review X >Chromatin Compaction, Auxeticity, and the Epigenetic Landscape of Stem Cells
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Chromatin Compaction, Auxeticity, and the Epigenetic Landscape of Stem Cells

机译：染色质压实，辅助性和干细胞的表观遗传景观

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When embryonic stem cells differentiate, the mechanical properties of their nuclei evolve en route to their terminal state. Measurements of the deformability of cell nuclei in the transitional state that intervenes between the embryonic stem-cell state and the differentiation primed state of mouse stem cells indicate that such nuclei are auxetic; i.e., they have a negative Poisson’s ratio. We show, using a theoretical model, how this remarkable mechanical behavior results from the coupling between chromatin compaction states and nuclear shape. Our biophysical approach, which treats chromatin as an active polymer system whose mechanics is modulated by nucleosome binding and unbinding, reproduces experimental results. It provides testable predictions for changes in chromatin compaction as a function of applied force, for the correlations of chromatin compaction and nuclear shape, and for the in-phase and out-of-phase response of these quantities to an applied uniaxial oscillatory force. Our model yields a biophysical interpretation of the epigenetic landscape of stem cells, also suggesting how this landscape might be probed experimentally.
机译：当胚胎干细胞分化时，它们的核的机械性能在其端子状态的途中发展。测量在胚胎干细胞状态和小鼠干细胞的分化引发状态之间干预的过渡状态下细胞核的可变形性表明，这种核是静脉的;即，他们有负泊松比例。我们使用理论模型显示这种显着的机械行为如何产生染色质压实状态和核形状之间的偶联。我们将染色质视为作为活性聚合物体系的生物物理方法，其力学通过核体结合和解耦来调节，再现实验结果。它为染色质压实和核形状的相关性提供了作为施加力的函数的染色质压实的变化的可测试预测，以及这些数量的相位和相响应的相位与应用的单轴振荡力。我们的模型产生了干细胞的表观遗传景观的生物物理解释，也表明如何通过实验探测这种景观。

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