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首页> 外文期刊>Physical Review X >Two-Species Active Transport along Cylindrical Biofilaments is Limited by Emergent Topological Hindrance
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Two-Species Active Transport along Cylindrical Biofilaments is Limited by Emergent Topological Hindrance

机译：两种沿圆柱形生物含量的主动运输受到紧急拓扑障碍的限制

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Active motion of molecules along filamentous structures is a crucial feature of cell biology and is often modeled with the paradigmatic asymmetric simple exclusion process. Motivated by recent experimental studies that have addressed the stepping behavior of kinesins on microtubules, we investigate a lattice gas model for simultaneous transport of two species of active particles on a cylinder. The species are distinguished by their different gaits: While the first species moves straight ahead, the second follows a helical path. We show that the collective properties of such systems critically differ from those of one-species transport in a way that cannot be accounted for by standard models. This is most evident in a jamming transition far below full occupation, as well as in nonequilibrium pattern formation. The altered behavior arises because—unlike the case in single-species transport—any given position may be targeted by two particles from different directions at the same time. However, a particle can leave a given position only in one direction. This simple change in connectivity significantly amplifies the impact of steric interactions and thus becomes a key determinant of mixed species transport. We computationally characterize this type of hindrance and develop a comprehensive theory for collective two-species transport along a cylinder. Our observations show high robustness against model extensions that account for additional biomolecular features and demonstrate that even small fractions of a second species can significantly alter transport. This suggests that our analysis is also relevant in a biological context.
机译：沿丝状结构的分子的主动运动是细胞生物学的关键特征，并且通常用矛盾的不对称简单排除过程进行建模。通过最近的实验研究，已经解决了Kinesins对微管的步进行为，我们研究了一种晶格气模型，用于同时运输两种活性颗粒在汽缸上。这些物种的特征在于它们的不同的Gaits：虽然第一个物种直线移动，但第二个呈螺旋路径。我们表明，这种系统的集体属性与一个物种运输的方式统治地不同，这种方式不能通过标准模型占据。这在远远低于全职职业的干扰过渡以及非QuibiRibrib模式形成中最明显。改变的行为产生，因为 - 与单一物种的情况不同，传送 - 任何给定位置可以同时由两个颗粒靶向。然而，颗粒可以仅在一个方向上留下给定位置。这种简单的连接变化显着放大了空间相互作用的影响，从而成为混合物种运输的关键决定因素。我们计算地表征了这种类型的障碍，并开发了沿气缸集体两种传输的全面理论。我们的观察结果显示出对额外生物分子特征的模型延伸的高稳健性，并表明即使是第二种种类的小部分也可以显着改变运输。这表明我们的分析在生物学背景下也相关。

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