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首页> 外文期刊>Physiological Reports >Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans
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Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans

机译：阳极经颅直流刺激对人类诱发电位变异性的影响

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Motor evoked potentials (MEPs) obtained from transcranial magnetic stimulation (TMS) allow corticospinal excitability (CSE) to be measured in the human primary motor cortex (M1). CSE responses to transcranial direct current stimulation (tDCS) protocols are highly variable. Here, we tested the reproducibility and reliability of individual MEPs following a common anodal tDCS protocol. In this study, 32 healthy subjects received anodal tDCS stimulation over the left M1 for three durations (tDCS‐T5, tDCS‐T10, and tDCS‐T20?min) on separate days in a crossover‐randomized order. After the resting motor threshold (RMT) was determined for the contralateral first dorsal interosseous muscle, 15 single pulses 4–8?sec apart at an intensity of 120% RMT were delivered to the left M1 to determine the baseline MEP amplitude at T 0 , T 5 , T 10 , T 20 , T 30 , T 40 , T 50 , and T 60 ?min after stimulation for each durations. During TMS delivery, 3D images of the participant's cortex and hot spot were visualized for obtaining MEPs from same position. Our findings revealed that there was a significant MEPs improvement at T 0 ( P ?=?0.01) after 10?min of anodal stimulation. After the 20‐min stimulation duration, MEPs differed specifically at T 0, T 5, T 30 ?min ( P ??0.05). This indicates that tDCS is a promising tool to improve MEPs. Our observed variability in response to the tDCS protocol is consistent with other noninvasive brain stimulation studies.
机译：从经颅磁刺激（TMS）获得的电动机诱发电位（MEP）允许在人初级马达皮质（M1）中测量皮质脊髓兴奋性（CSE）。 CSE对经颅直流刺激（TDCS）协议的反应是高度可变的。在这里，我们通过常见的AnoDal TDCS协议进行了对单个MEP的再现性和可靠性。在本研究中，32个健康受试者在交叉随机顺序的单独日期，在左侧M1上接受左侧M1的阳极TDCs刺激，以交叉随机顺序的单独的日子在单独的日子上。在确定对侧的对侧第一背体肌肉的静息电机阈值（RMT）之后，将15个单脉冲4-8ΔSEC分开在120％RMT的强度，左侧M1递送，以确定T 0的基线MEP振幅，对于每个持续时间，T 5，T 10，T 20，T 30，T 40，T 50和T 60？min刺激后。在TMS交付期间，可视化参与者皮质和热点的3D图像以获得来自相同位置的MEP。我们的研究结果显示，在10次阳极刺激后，T 0（P？= 0.01）有显着的MEPs改善。在20分钟的刺激持续时间后，MEPs特异性在T 0，T 5，T 30？min（P？<β05）不同。这表明TDC是改进MEPS的有希望的工具。我们观察到响应TDCS协议的可变性与其他无血糖刺激研究一致。

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