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首页> 外文期刊>Physiological Reports >Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice
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Phenotypic effects of dietary stress in combination with a respiratory chain bypass in mice

机译：膳食应激与小鼠呼吸链旁路组合的表型效应

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The alternative oxidase (AOX) from Ciona intestinalis was previously shown to be expressible in mice and to cause no physiological disturbance under unstressed conditions. Because AOX is known to become activated under some metabolic stress conditions, resulting in altered energy balance, we studied its effects in mice subjected to dietary stress. Wild‐type mice ( Mus musculus , strain C57BL/6JOlaHsd) fed a high‐fat or ketogenic (high‐fat, low‐carbohydrate) diet show weight gain with increased fat mass, as well as loss of performance, compared with chow‐fed animals. Unexpectedly, AOX‐expressing mice fed on these metabolically stressful, fat‐rich diets showed almost indistinguishable patterns of weight gain and altered body composition as control animals. Cardiac performance was impaired to a similar extent by ketogenic diet in AOX mice as in nontransgenic littermates. AOX and control animals fed on ketogenic diet both showed wide variance in weight gain. Analysis of the gut microbiome in stool revealed a strong correlation with diet, rather than with genotype. The microbiome of the most and least obese outliers reared on the ketogenic diet showed no consistent trends compared with animals of normal body weight. We conclude that AOX expression in mice does not modify physiological responses to extreme diets.
机译：从CiONa肠道的替代氧化酶（AOX）先前被证明是在小鼠中可达的，并且在无重点条件下不会导致生理干扰。由于已知AOX在一些代谢应激条件下被激活，因此导致能量平衡改变，我们研究了对经膳食应激的小鼠的影响。喂养高脂肪或酮症（高脂肪，低碳水化合物）饮食的野生型小鼠（菌株C57BL / 6JOLAHSD）显示体重增加，脂肪质量增加，而且性能损失，与食头喂养相比动物。出乎意料地，在这些代谢上压力，富含脂肪的饮食中喂养的AOX表达小鼠表现出几乎无法区分的体重增加和改变的身体组成作为对照动物。在非转基因凋落物中，在AX小鼠中酮饮食在类似程度上损害了心脏能。 AX和对照动物喂养酮味的饮食均显示重量增益的广泛方差。粪便中肠道微生物组的分析显示出与饮食的强烈相关，而不是基因型。与正常体重的动物相比，在酮饮食上饲养的最多肥胖异常值的微生物组无一致趋势。我们得出结论，小鼠中的AOX表达不会改变生理反应对极端饮食。

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