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Neurobiological origins of individual differences in mathematical ability

机译：数学能力中个体差异的神经生物学起源

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Mathematical ability is heritable and related to several genes expressing proteins in the brain. It is unknown, however, which intermediate neural phenotypes could explain how these genes relate to mathematical ability. Here, we examined genetic effects on cerebral cortical volume of 3–6-year-old children without mathematical training to predict mathematical ability in school at 7–9 years of age. To this end, we followed an exploration sample ( n = 101) and an independent replication sample ( n = 77). We found that ROBO1 , a gene known to regulate prenatal growth of cerebral cortical layers, is associated with the volume of the right parietal cortex, a key region for quantity representation. Individual volume differences in this region predicted up to a fifth of the behavioral variance in mathematical ability. Our findings indicate that a fundamental genetic component of the quantity processing system is rooted in the early development of the parietal cortex.
机译：数学能力是遗传性的，与脑中蛋白质表达蛋白质的几个基因有关。然而，这是未知的，其中中间神经表型可以解释这些基因如何与数学能力有关。在这里，我们检查了3-6岁儿童的脑皮质体积的遗传效应，没有数学训练，以预测学校的数学能力在7 - 9岁。为此，我们遵循探索样本（n = 101）和独立的复制样本（n = 77）。我们发现Robo1，一种已知调节脑皮质层产前生长的基因与右侧皮质的体积相关，其数量表示的关键区域。该区域中的个体体积差异预测了数学能力的行为方差的第五次。我们的研究结果表明，数量加工系统的基本遗传组分植根于榫氏皮质的早期发展。

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