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首页> 外文期刊>PLoS Genetics >Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks
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Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks

机译：作者：张莹莹，王莹，王莹，王莹，王莹，王莹，王莹，王莹，王莹

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Animals exhibit dramatic immediate behavioral plasticity in response to social interactions, and brief social interactions can shape the future social landscape. However, the molecular mechanisms contributing to behavioral plasticity are unclear. Here, we show that the genome dynamically responds to social interactions with multiple waves of transcription associated with distinct molecular functions in the brain of male threespined sticklebacks, a species famous for its behavioral repertoire and evolution. Some biological functions (e.g., hormone activity) peaked soon after a brief territorial challenge and then declined, while others (e.g., immune response) peaked hours afterwards. We identify transcription factors that are predicted to coordinate waves of transcription associated with different components of behavioral plasticity. Next, using H3K27Ac as a marker of chromatin accessibility, we show that a brief territorial intrusion was sufficient to cause rapid and dramatic changes in the epigenome. Finally, we integrate the time course brain gene expression data with a transcriptional regulatory network, and link gene expression to changes in chromatin accessibility. This study reveals rapid and dramatic epigenomic plasticity in response to a brief, highly consequential social interaction.
机译：动物表现出巨大的直接行为可塑性，以应对社会互动，并且简短的社会互动可以塑造未来的社会景观。然而，有助于行为可塑性的分子机制尚不清楚。在这里，我们表明该基因组动态地响应了与男性繁殖汗疱疹大脑中不同分子功能相关的社交交互，该物种是其行为曲目和演化而着名的物种。在短暂的领土挑战之后，一些生物学功能（例如，激素活性）很快达到顶峰，然后拒绝其他（例如，免疫反应）之后的几个小时。我们识别预测坐标与行为可塑性不同组分相关的转录波的转录因子。接下来，使用H3K27AC作为染色质可用性的标记，我们表明简短的领土入侵足以导致外延蛋白酶的快速和显着变化。最后，我们将时间脑脑基因表达数据与转录调节网络相结合，并将基因表达链接至染色质可用性的变化。本研究揭示了快速和显着的表观态可塑性，以应对简短，高度相应的社会互动。

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