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The emerging role of transcriptional regulation in the oocyte-to-zygote transition

机译：转录调控在卵母细胞对Zygote转变中的新兴作用

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Fertilization marks the beginning of a new life by converting two terminally differentiated gametes into a single totipotent zygote. Central to this transition is a complex biological pro- gram commonly referred to as oocyte activation—an umbrella term for a series of profound changes that prepare the fertilized oocyte for totipotency [1, 2]. These include, among others, the completion of meiosis, the formation of the two pronuclei, and the selective translation of maternal RNAs. A remarkable aspect of oocyte activation is that it occurs in the absence of transcription. Not surprisingly, most of our knowledge of this process is centered on the post- transcriptional regulation of gene expression [3]. Yet, a recent body of evidence has brought new focus on the fundamental importance of transcriptional regulation during oogenesis as a primer for the oocyte-to-zygote transition [4].
机译：通过将两个终端差异化的配子转化为单一的Totipotent精致，施肥标志着新生活的开始。该转变的核心是一种复杂的生物蛋白，通常称为卵母细胞活化 - 一系列深度变化的伞术语，用于制备受精卵母细胞[1,2]。其中包括患有分裂，形成两期的形成，以及母体RNA的选择性翻译。卵母细胞活化的显着方面是它在没有转录的情况下发生。毫不奇怪，我们对这一过程的大部分知识都是以基因表达的转录后调节为中心[3]。然而，最近的一系列证据带来了新的重点是oOcyte-to-ygoToTe转变的底漆过程中转录调节的基本重要性[4]。

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