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首页> 外文期刊>PLoS Genetics >Parallel and nonparallel genomic responses contribute to herbicide resistance in Ipomoea purpurea, a common agricultural weed
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Parallel and nonparallel genomic responses contribute to herbicide resistance in Ipomoea purpurea, a common agricultural weed

机译：平行和非平行的基因组反应有助于除草剂抗药物抗药物抗药物在<斜视素紫癜和常见的农业杂草中

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The repeated evolution of herbicide resistance has been cited as an example of genetic parallelism, wherein separate species or genetic lineages utilize the same genetic solution in response to selection. However, most studies that investigate the genetic basis of herbicide resistance examine the potential for changes in the protein targeted by the herbicide rather than considering genome-wide changes. We used a population genomics screen and targeted exome re-sequencing to uncover the potential genetic basis of glyphosate resistance in the common morning glory, Ipomoea purpurea , and to determine if genetic parallelism underlies the repeated evolution of resistance across replicate resistant populations. We found no evidence for changes in 5‐enolpyruvylshikimate‐3‐phosphate synthase ( EPSPS ), glyphosate’s target protein, that were associated with resistance, and instead identified five genomic regions that showed evidence of selection. Within these regions, genes involved in herbicide detoxification—cytochrome P450s, ABC transporters, and glycosyltransferases—are enriched and exhibit signs of selective sweeps. One region under selection shows parallel changes across all assayed resistant populations whereas other regions exhibit signs of divergence. Thus, while it appears that the physiological mechanism of resistance in this species is likely the same among resistant populations, we find patterns of both similar and divergent selection across separate resistant populations at particular loci.
机译：已经引用了除草剂抗性的重复演变作为遗传平行性的一个例子，其中单独的物种或遗传谱系使用相同的遗传溶液响应于选择。然而，研究除草剂抗性的遗传基础的大多数研究检查了除草剂靶向的蛋白质变化的可能性，而不是考虑到全基因组的变化。我们使用群体基因组学筛网并针对exome重新测序，以发现常见的辉煌，Ipomoea purpurea在常见的辉煌中灭绝的潜在遗传基础，并确定遗传平行性是否在重复抗性群体中反复演变。我们发现没有据证明5-烯醇吡咯胆管 - 3-磷酸盐合成酶（EPSP），草甘膦的靶蛋白，其与抗性相关，而是鉴定出五种基因组区域，显示出选择的选择证据。在这些区域内，参与除草剂排毒 - 细胞色素P450s，ABC转运蛋白和糖基转移酶的基因 - 被富集和表现出选择性扫描的迹象。选择下的一个区域显示了所有测定的抗性群体的平行变化，而其他地区表现出分歧的迹象。因此，虽然似乎在抗性群体中可能相同的抗性的生理机制可能相同，但我们发现特定基因座的独立抗性群体相似和发散的选择模式。

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