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首页> 外文期刊>PLOS Neglected Tropical Diseases >Discrepant Prevalence and Incidence of Leishmania Infection between Two Neighboring Villages in Central Mali Based on Leishmanin Skin Test Surveys
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Discrepant Prevalence and Incidence of Leishmania Infection between Two Neighboring Villages in Central Mali Based on Leishmanin Skin Test Surveys

机译：基于Leishmanin皮肤测试调查的马里中部两个邻近村庄的Leishmania感染的普遍存在和发病率

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Apart from a single report, the last publication of cutaneous leishmaniasis (CL) in Mali dates back more than 20 years. The absence of information on the current status of CL in Mali led us to conduct a cohort study in Kemena and Sougoula, two villages in Central Mali from which cases of CL have been recently diagnosed by Mali's reference dermatology center in Bamako. In May 2006, we determined the baseline prevalence of Leishmania infection in the two villages using the leishmanin skin test (LST). LST-negative individuals were then re-tested over two consecutive years to estimate the annual incidence of Leishmania infection. The prevalence of Leishmania infection was significantly higher in Kemena than in Sougoula (45.4% vs. 19.9%; OR: 3.36, CI: 2.66–4.18). The annual incidence of Leishmania infection was also significantly higher in Kemena (18.5% and 17% for 2007 and 2008, respectively) than in Sougoula (5.7% for both years). These data demonstrate that the risk of Leishmania infection was stable in both villages and confirm the initial observation of a significantly higher risk of infection in Kemena (OR: 3.78; CI: 2.45–6.18 in 2007; and OR: 3.36; CI: 1.95–5.8 in 2008; P<0.005). The absence of spatial clustering of LST-positive individuals in both villages indicated that transmission may be occurring anywhere within the villages. Although Kemena and Sougoula are only 5 km apart and share epidemiologic characteristics such as stable transmission and random distribution of LST-positive individuals, they differ markedly in the prevalence and annual incidence of Leishmania infection. Here we establish ongoing transmission of Leishmania in Kemena and Sougoula, Central Mali, and are currently investigating the underlying factors that may be responsible for the discrepant infection rates we observed between them.
机译：除了单一报告之外，马里的皮肤利什曼病（CL）的最后一份出版物会追溯到20多年。没有关于MALI CL目前地位的信息导致我们在Kemena和Sougoula进行群组，马里中部的两个村庄在Mali在巴马科的参考皮肤病学中心诊断出来。 2006年5月，我们确定了使用Leishmanin皮肤测试（LST）在两个村庄的Leishmania感染的基线患病率。然后，LST阴性个体连续两年重新测试，以估算Leishmania感染的年发病率。 Kemena的Leishmania感染的患病率明显高于Sougoula（45.4 ％Vs.19.9 ％;或：3.36，CI：2.66-4.18）。 Kemena的年龄发生率也明显高于育川（2007年和2008年）显着提高（18.5‰，2008年，两年的5.7％）。这些数据表明，狼疮感染的风险在村庄中稳定，并确认初步观察KEMENA（或：3.78; CI：2.45-6.18在2007年的初始感染风险;和或：3.36; CI：1.95- 5.8 2008年; P <0.005）。在两个村庄中没有LST阳性个体的空间聚类表明，可以在村庄内的任何地方发生传输。虽然Kemena和Sougoula仅5公里，但分享了流行病学特征，如Lst-阳阳性的稳定传播和随机分布，患有患病率和Leishmania感染的年度发生率显着不同。在这里，我们在马里克米纳和萨富拉的Leishmania建立了持续的传播，目前正在调查可能对我们之间观察到的差异感染率负责的潜在因素。

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