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首页> 外文期刊>PLOS Neglected Tropical Diseases >The Incidence of Human Cysticercosis in a Rural Community of Eastern Zambia
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The Incidence of Human Cysticercosis in a Rural Community of Eastern Zambia

机译：在赞比亚东部农村群体中人囊霉菌发生率

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A community-based longitudinal study was performed in the Eastern Province of Zambia, in which repeated serological samplings were done to determine the incidence of human cysticercosis. Three sampling rounds were carried out at six months intervals. A total of 867 participants presented for all three samplings. All samples were tested for the presence of cysticercus antigens using a monoclonal antibody-based enzyme-linked immunosorbent assay (sero-Ag-ELISA), while a randomly selected sub-sample of 161 samples from each sampling round was tested for specific antibodies using a commercial enzyme-linked immunoelectrotransfer blot (EITB) assay. Stool samples (n?=?226) were also collected during the final round of sampling for taeniosis diagnosis by coprology and coproantigen ELISA. Cysticercosis seroprevalence varied from 12.2% to 14.5% (sero-Ag) and from 33.5% to 38.5% (sero-Ab) during the study period. A taeniosis prevalence of 11.9% was determined. Incidence rates of 6300 (sero-Ag, per 100000 persons-year) and 23600 (sero-Ab, per 100000 persons-year) were determined. Seroreversion rates of 44% for sero-Ag and 38.7% for sero-Ab were recorded over the whole period. In conclusion, this study has shown the dynamic nature of T. solium infections; many of the people at risk become (re)infected due to the high environmental contamination, with a high number turning seronegative within a year after infection. An important number of infections probably never fully establish, leading to transient antibody responses and short-term antigen presence.
机译：在赞比亚东部进行了一项以社区为基础的纵向研究，其中重复血清学抽样以确定人囊霉菌的发生率。三个采样轮以六个月的间隔进行。共有867名参与者为所有三个采样提供。使用单克隆抗体的酶联免疫吸附测定（Sero-Ag-ELISA）测试所有样品的所有样品，同时使用a的特异性抗体检查来自每个取样圆的161个样品的随机选择的亚样品。商业酶联免疫电动晶片印迹（EITB）测定。在通过共同循环诊断的最后一轮抽样期间还收集了粪便样品（N？= 226），用于通过共同病变和共蛋白酶诊断。囊尾蚴病在研究期间，血糖体静脉升压从12.2％至14.5％（血清-AG）和33.5％至38.5％（Sero-AB）不同。确定了11.9％的大尖症患病率。确定了6300（每10万人）和23600（每10万人血清AG，每10万人）的发病率。在整个期间记录Sero-Ag的44％的血液转化率和38.7％的血清-B。总之，本研究表明了T.棒感染的动态性质;风险的许多人因环境污染的高污染而感染（重新），在感染后一年内达到血清的大量。重要的感染可能从未完全建立，导致瞬时抗体反应和短期抗原存在。

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