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首页> 外文期刊>PLOS Neglected Tropical Diseases >Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei
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Presence of B. thailandensis and B. thailandensis expressing B. pseudomallei-like capsular polysaccharide in Thailand, and their associations with serological response to B. pseudomallei

机译：在泰国的B.泰国人和B.泰国人表达B.Pseudomallei样囊多糖，以及与B.Pseudomallei的血清学反应的关联

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Author summary Burkholderia thailandensis is a non-pathogenic soil-dwelling bacterium and is genetically closely related to Burkholderia pseudomallei, the cause of melioidosis. In mouse models, inoculation of a variant of B. thailandensis which express a B. pseudomallei-like capsular polysaccharide (BTCV) induces antibodies and partial protection against melioidosis. Here, we evaluated the presence of B. pseudomallei, B. thailandensis, and BTCV in 61 rice fields in Northeast, East and Central Thailand, determined whether they co-existed, and if their presence was associated with a serological response in farmers. We report the presence of BTCV in Thailand for the first time and describe the distribution of the three organisms. Co-localization between these organisms in the same rice fields was not uncommon. Our findings suggested that serological positivity based on the indirect hemagglutination assay (a test commonly used to detect antibodies to B. pseudomallei) in healthy rice farmers in Thailand was associated with exposure to B. pseudomallei, but not exposure to B. thailandensis or BTCV.
机译：作者摘要Burkholderia Thailandensis是一种非致病土壤 - 居住的细菌，其与Burkholderia pseudomallei有遗传密切相关，融化剂的原因。在小鼠模型中，接种B.泰国的变体，其表达B.Pseudomallei样囊多糖（BTCV）诱导抗体和部分保护免受醚类。在此，我们评估了B.Pseudomallei，B.泰国人和东北部的61个稻田的BTCV，泰国东部和中部地区的BTCV确定了它们是否共存，以及他们的存在与农民中的血清学反应有关。我们首次报告泰国BTCV的存在，并描述了三种生物的分布。在同一稻田中这些生物之间的共同定位并不少见。我们的研究结果表明，基于间接血凝测定的血清学阳性（常用于泰国健康水稻农民中常用于B.Pseudomallei的试验）与B.Pseudomallei的暴露有关，但不会接触B.泰国人或BTCV。

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