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首页> 外文期刊>PLOS Neglected Tropical Diseases >Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies
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Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies

机译：口服浸润性沙门氏菌抑制侵入性浸润性的IgA和IgG单克隆抗体

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The bacterium Salmonella enterica is responsible for significant morbidity and mortality in the developed and developing worlds. While the pathogen is most renowned as the causative agent of typhoid fever, the emergence of invasive non-typhoid strains like S. enterica serovar Typhimurium (STm) are of great concern because of their propensity to cause severe disease in children under the age of five. In this report, we demonstrate in a mouse model that oral administration of a monoclonal antibody targeting the surface of STm is able to prevent the bacterium from infecting gastrointestinal tissues, the first step in the dissemination process. We show that IgA antibodies (which are normally found in the gut) were far superior than an equivalent IgG antibody (normally found in blood) at defending the intestine from STm infection. These results lay the foundation for future studies aimed at the development of an orally administered antibody cocktail capable of providing temporary immunity to pathogens like S. enterica.
机译：细菌沙门氏菌肠道是发达国家和发展中国家的显着发病率和死亡率。虽然病原体最着名作为伤寒症的致病剂，但侵入性非伤寒菌株的出现，如S.肠道毒蕈伤寒毒蕈（STM）是非常关注的，因为它们在五岁以下儿童造成严重疾病的倾向。在本报告中，我们在小鼠模型中证明了靶向STM表面的单克隆抗体的口服施用能够防止细菌感染胃肠组织，这是传播过程中的第一步。我们表明IgA抗体（通常在肠道中发现）远低于在从STM感染的肠道辩护中的等效IgG抗体（通常在血液中发现）。这些结果为未来的研究奠定了旨在旨在开发口服给药的抗体鸡尾酒，能够为肠溶细胞提供暂时性免疫的口服抗体鸡尾酒。

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