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Experimental oral transmission of chronic wasting disease to sika deer ( Cervus nippon )

机译：慢性浪费疾病对锡卡鹿（Cervus nippon）的实验口服传播

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Chronic wasting disease (CWD) affects a broad array of cervid species and continues to be detected in an expanding geographic range. Initially introduced into the Republic of Korea through the importation of CWD-infected elk ( Cervus canadensis ), additional cases of CWD were subsequently detected in farmed Korean elk and sika deer ( Cervus nippon ). Wild and farmed sika deer are found in many regions of Asia, North America, and Europe, although natural transmission to this species has not been detected outside of the Republic of Korea. In this study, the oral transmission of CWD to sika deer was investigated using material from CWD-affected elk. Pathological prion (PrPsupCWD/sup) immunoreactivity was detected in oropharyngeal lymphoid tissues of one sika deer at 3.9?months post-inoculation (mpi) and was more widely distributed in a second sika deer examined at 10.9 mpi. The remaining four sika deer progressed to clinical disease between 21 and 24 mpi. Analysis of PrPsupCWD/sup tissue distribution in clinical sika deer revealed widespread deposition in central and peripheral nervous systems, lymphoreticular tissues, and the gastrointestinal tract. Prion protein gene ( PRNP ) sequences of these sika deer were identical and consistent with those reported in natural sika deer populations. These findings demonstrate the efficient oral transmission of CWD from elk to sika deer.
机译：慢性浪费疾病（CWD）影响广泛的颈椎阵列，并继续在扩大的地理范围内检测。最初通过进口CWD感染的麋鹿（Cervus Canadensis）引入大韩民国，随后在农林韩国麋鹿和锡卡鹿（Cervus Nippon）中检测到额外的CWD病例。野生和养殖的锡卡鹿在亚洲，北美和欧洲的许多地区发现，尽管韩国共和国尚未发现对此物种的自然传播。在这项研究中，使用来自影响CWD受影响的麋鹿的材料来研究CWD至SIKA鹿的口服传输。在接种后的3.9℃的淋巴淋巴结组中检测到病理朊病毒（PRP CWD ）免疫反应性，在接种后（MPI）中，在10.9mPi检查的第二个SIKA鹿中更广泛地分布。剩下的四个西卡鹿在21至24％的MPI之间进行至临床疾病。 PRP CWD 组织分布在临床锡卡鹿中的组织分布揭示了中环和外周神经系统，淋巴组织和胃肠道的广泛沉积。这些Sika鹿的朊病毒蛋白基因（PRNP）序列与天然Sika鹿群报道的那些相同且一致。这些调查结果表明了CWD从麋鹿到锡卡鹿的高效口头传输。

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