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首页> 外文期刊>Pulmonary therapy. >Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study
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Can the Number of Radiofrequency Activations Predict Serious Adverse Events after Bronchial Thermoplasty? A Retrospective Case-Control Study

机译：射频激活的数量可以在支气管热塑术后预测严重不良事件？回顾性案例控制研究

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IntroductionBronchial thermoplasty (BT) is a bronchoscopic procedure that involves the delivery of thermal radiofrequency energy to the bronchial wall for treating severe asthma. It has been suggested that too many radiofrequency activations could induce serious adverse events (SAEs) at an early stage. We aimed to examine the number of radiofrequency activations at each session and early lung function changes from baseline to determine whether these are related to SAEs. MethodsWe retrospectively investigated 13 consecutive patients who underwent three sessions each of BT for severe asthma from February 2015 to January 2016. Lung function tests were performed on the day before and after each BT procedure. Since we compared the number of activations and lung function changes from baseline after each session, a total of 39 sessions were reviewed. The relationship between the number of radiofrequency activations and each lung function change from baseline was also examined by linear regression analysis. ResultsA total of 10 SAEs (4 of pneumonia, 3 of atelectasis, 2 of bronchial asthma exacerbation and 1 of hemoptysis) were observed following the 39 BT sessions. When we compared sessions with and without SAEs, there were no differences in the number of activations (mean?±?SD, 71.5?±?28.6 times in sessions with SAEs; 66.5?±?25.1 times in sessions without SAEs; p =?0.772) and lung function changes (mean changes in FVC/%FVC/FEVsub1/sub/%FEVsub1/sub/%PEF from baseline; ??0.49 l/??14.2%/??0.36 l/??11.7%/??9.6% in sessions with SAEs; ??0.43 l/??13.3%/??0.34 l/??12.1%/??9.4% in sessions without SAEs; p ?0.05 for all the above). Increase in the number of activations correlated with decreased FEVsub1/sub ( R sup2/sup?=?0.17, p =?0.0088) and %FEVsub1/sub ( R sup2/sup?=?0.11, p =?0.0357). ConclusionsIncrease in the number of radiofrequency activations during BT is related to a decrease in FEVsub1/sub and %FEVsub1/sub from baseline. The number of radiofrequency activations, however, is not associated with SAEs after BT.
机译：介绍核影热术（BT）是支气管镜手术，涉及将热射频能量输送到支气管壁以治疗严重的哮喘。已经提出，太多的射频激活可以在早期阶段引起严重不良事件（SAES）。我们旨在检查每个会议的射频激活数，早期的肺功能从基线改变，以确定这些是否与Saes有关。方法技术回顾性地调查了13名连续的患者，从2015年2月到2016年1月，每次BT为严重哮喘进行三次会议。肺功能测试在每次BT程序前后进行。由于我们比较了每次会议后从基线变化的激活和肺功能的数量，因此综述了39个会议。通过线性回归分析还检查了射频激活数量和基线的每个肺功能的关系。在39英尺的会话之后，观察到结果在39英镑季节后观察到总共10个SAES（4个肺炎，间距，2个支气管哮喘和咯血和1个）。当我们与没有SAES的会话进行比较时，激活的数量没有差异（平均值？±？SD，71.5？±28.6次与SAES的会话中; 66.5？±25.1次没有SAES; P =？ 0.772）和肺功能变化（FVC /％FVC / FEV 1 /％FEV 1 /％PEF从基线的PEF; ?? 0.49 L / ?? 14.2％ / ??? 0.36 L / ?? 11.7％/ ?? 9.6％在塞斯的会话中; ?? 0.43升/ ?? 13.3％/ ?? 0.34 L / ?? 12.1％/ ??在没有SAES的会话中的12.1％/ ?? 9.4％; P >以上所有的？0.05）。与减小的FEV 1 （R 2 Δ=Δ0.17，p =Δ0.0088）和％fev 1 （ R 2 ？=？0.11，p = 0.0357）。结论BT期间的射频激活数量的释放与基线的FEV 1 和％fev 1 的减少有关。然而，射频激活的数量与BT之后的SAE无关。

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