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首页> 外文期刊>Pulmonary therapy. >Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
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Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis

机译：肺功能测量与毒性毒性毒性和成人的比较反应，患有哮喘剧性：术后分析

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IntroductionAirway obstruction is usually assessed by measuring forced expiratory volume in 1?s (FEVsub1/sub), forced vital capacity (FVC) and peak expiratory flow (PEF). This post hoc study investigated comparative responses of lung function measurements in adults and adolescents (full analysis set, N =?3873) following treatment with tiotropium Respimatsup?/sup.MethodsLung function outcomes were analysed from five phase III trials in adults (≥?18?years) with symptomatic severe, moderate and mild asthma (PrimoTinA-asthmasup?/sup, MezzoTinA-asthmasup?/sup and GraziaTinA-asthmasup?/sup, respectively), and one phase III trial in adolescents (12–17?years) with symptomatic moderate asthma (RubaTinA-asthmasup?/sup). Changes from baseline versus placebo in FEVsub1/sub, FVC, PEF and FEVsub1/sub/FVC ratio with tiotropium 5?μg or 2.5 μg added to at least stable inhaled corticosteroids at week 24 (week 12 in GraziaTinA-asthma) were analysed.ResultsAll lung function measures improved in all studies with tiotropium 5?μg (mean change from baseline versus placebo), including peak FEVsub1/sub (110–185?mL), peak FVC (57–95?mL) and morning PEF (15.8–25.6 L/min). Changes in adolescents were smaller than those in adults, and were statistically significant primarily for FEVsub1/sub and PEF, but not for FVC.ConclusionConsistent improvements were seen across all lung function measures with the addition of tiotropium to other asthma treatments in adults across all severities, whereas the improvements with tiotropium in adolescents primarily impacted measures of flow rather than lung volume. This may reflect less pronounced airway remodelling and air trapping in adolescents with asthma versus adults.
机译：引言梗阻通常通过测量1？S（FEV 1 ），强制生命能力（FVC）和峰值呼气流量（PEF）来评估强制呼气量。该后HOC研究研究了肺功能测量的对比应对成人和青少年（完全分析集，N =β3873）在用噻托溴铵治疗后进行治疗，从5阶段III试验中分析了5期III阶段的疗法结果.Methodslung函数结果成年人（≥18岁？年）患有症状严重，中度和轻度哮喘（PRIMOTINA-ASTHMA ，Mezzotina-ASTHMA αsβ-和Graziatina-anthma ？，分别）和一期在青少年（12-17岁）的一期III试验，具有症状中度哮喘（Rubatina-anthma β-）。从基线与安慰剂的变化在FEV 1 ，fvc，pef和fev 1 / fvc 1 / fvc 1 / fvc比率，在第24周加入至少稳定的吸入皮质类固醇（Graziatina-anthma的第12周）进行了分析。肺活量的肺功能措施改善了噻托溴铵5？μg（从基线与安慰剂的平均变化），包括峰FEV 1 （110-185？ml ），峰FVC（57-95？ml）和晨巾（15.8-25.6L / min）。青少年的变化小于成年人那些人，并且主要针对FEV 1 和PEF统计学意义，但不适用于FVC。在所有肺功能措施中，在其他哮喘中，所有肺功能措施都会看到合并措施。在所有严重主义中的成人治疗，而脱毒液在青少年的改善主要受到流动措施而不是肺部量。这可能反映了哮喘与成年人的青少年的较不明显的气道重塑和空气捕获。

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