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首页> 外文期刊>Ukrainian Biochemical Journal >Peculiarities of ammonia metabolism in the liver of rats under the conditions of different nutrients content in a diet
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Peculiarities of ammonia metabolism in the liver of rats under the conditions of different nutrients content in a diet

机译：饮食中不同营养素含量含量肝脏肝脏肝脏氨代谢的特性

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The peculiarities of the metabolic transformations of ammonia in the liver of rats under the conditions of protein deprivation and high content of sucrose in the diet were studied in the research. It has been established that animals kept on high-sucrose (group III) and low-protein/high-sucrose diet (group IV) had hyperammonemia, whereas in rats maintained under the conditions of protein deficiency in the diet (group II) the blood level of ammonia nitrogen was within normal range. The revealed hyperammonemia in animals of the III and IV groups was accompanied by a marked decrease in the activity of mitochondrial enzymes, which provide a replenishment of the endogenous ammonia pool – glutamate dehydrogenase and monoamine oxidase, reaching the minimum values in conditions of the maintenance of animals on the high-sucrose diet. At the same time, there was a marked decrease in the activity of ammonia neutralization enzymes – carbamoyl phosphate synthetase, more significant in animals of the IV group, as well as glutamine synthetase. The obtained results allow us to conclude that the hyperammonemia revealed in animals maintained on the high-sucrose diet is not related to the enhanced formation of ammonia, but to the disturbances in the processes of its detoxification in the liver. At the same time, under the conditions of alimentary protein deprivation, a decrease in the activity of the key enzymes of ammonia formation (glutamate dehydrogenase and monoamine oxidase) and neutralization (carbamoyl phosphate synthetase and glutamine synthetase) is probably due to the lack of substrates for these enzymatic reactions. The obtained research results can be used to develop a strategy for correction of the disorders of ammonia metabolism under the conditions of different content of sucrose and protein in diet.
机译：研究了蛋白质剥夺和饮食中蔗糖高含量肝脏肝脏肝脏代谢转化的特性。已经建立了在高蔗糖（III族）和低蛋白质/高蔗糖饮食（IV组）上保持的动物具有高血肿性，而在饮食中蛋白质缺乏病症的大鼠中（II组）血液氨氮水平在正常范围内。 III和IV基团的动物的揭示的高血肿瘤伴随着线粒体酶活性的显着降低，其提供了内源性氨池 - 谷氨酸脱氢酶和单胺氧化酶的补充，达到了维护条件下的最小值高蔗糖饮食上的动物。同时，氨中和酶 - 氨基酰磷酸盐合成酶的活性显着降低，IV组的动物中更显着，以及谷氨酰胺合成酶。获得的结果使我们得出结论，在高蔗糖饮食中保持的动物中显示的高血症与增强的氨的形成无关，而是对肝脏中排毒过程中的紊乱无关。同时，在消化蛋白质剥夺的条件下，氨形成关键酶的活性（谷氨酸脱氢酶和单胺氧化酶）和中和（氨基甲酰基磷酸盐合成酶和谷氨酰胺合成酶）可能是由于缺乏底物对于这些酶促反应。所获得的研究结果可用于制定在饮食中蔗糖和蛋白质含量的条件下校正氨代谢紊乱的策略。

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