• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ukrainian Biochemical Journal >Protective action of N-stearoylethanolamine on blood coagulation and arterial changes in spontaneously hypertensive rats fed cholesterol-rich diet
【24h】

Protective action of N-stearoylethanolamine on blood coagulation and arterial changes in spontaneously hypertensive rats fed cholesterol-rich diet

机译：N-硬脂酰乙醇胺对自发性高血压大鼠血液凝血和动脉变化的保护作用富含胆固醇的饮食

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this work we aimed to test the atherosclerotic changes in the aortic wall and pro-coagulant response of the blood coagulation system of spontaneously hypertensive rats (SHR) fed cholesterol-rich diet (CRD) and to study the effect of the anti-inflammatory agent N-stearoylethanolamine (NSE) on the development of atherosclerosis in this model. Female rats ( n = 30) with genetically determined hypertension proven by direct measurement of blood pressure were fed CRD (5% cholesterol) for 2 months. Control group of SHR ( n = 10) received standard pellet diet, 10 were fed CRD and 10 received CRD with daily per os application of NSE at a dose of 50 mg/kg of body weight. Histological analysis detected swelling and detachment of endothelial cells, huge edema of the subendothelial layer and a disruption of the middle shell integrity. CRD rats had higher fibrinogen concentration, increased rate of platelet aggregation and decreased level of anticoagulant PC. Platelet aggregation speed increased in CRD-fed rats (52.5±4.1%/min) was slightly normalized under the action of NSE (40±8.3 vs 35±9%/min in controls). Fibrinogen concentration was slightly increased in CRD-fed rats (2.75±0.7 vs 1.9±0.5 mg/ml in controls). However, the level of anticoagulant PC that was decreased in CRD-fed rats (65±16 vs 100±11% in controls) was normalized under the action of NSE (92±17%). NSE also influenced the aorta architecture, however normalizing the thickness of the aorticwall did not change the cholesterol-induced inclusions within aorta media. NSE anti-inflammatory action changes the atherogenic processes in CRD-fed rats mainly protecting PC from consumption during the inflammatory process and reducing edema of the aorta. However hematological parameters (including clotting time in the APTT test and fibrinogen concentration) changed independently on NSE application. Anti-aggregatory action of NSE on platelets can be a result of direct action on platelets or the consequence of its anti-inflammatory action. During atherogenesis induced by CRD in the model, NSE demonstrated valuable anti-inflammatory action protecting the organism during atherogenesis, however it cannot be assumed as an antithrombotic or antiatherogenic agent because it is unable to influence hemostasis directly.
机译：在这项工作中，我们旨在测试自发性高血压大鼠（SHR）富含胆固醇的饮食（CRD）的自发性高血压大鼠（CRD）的血液凝固系统的主动脉粥样硬化性变化，并研究抗炎剂的作用N-Stearoylethanolamine（NSE）关于该模型动脉粥样硬化的发展。通过直接测量血压的血压测定的雌性大鼠（n = 30）被喂养CRD（5％胆固醇）2个月。对照组SHR（n = 10）接受了标准颗粒饮食，10次CRD和10个每天接受CRD，每次OS的NSE施用，剂量为50mg / kg体重。组织学分析检测到内皮细胞的肿胀和脱离，潜水层的巨大水肿和中间壳完整性的破坏。 CRD大鼠具有较高的纤维蛋白原浓度，血小板聚集率的增加和抗凝血PC水平降低。在CRD喂养大鼠（52.5±4.1％/ min）下血小板聚集速度在NSE的作用下略微归一化（40±8.3 Vs 35±9％/ min的对照）。 CRD馈电大鼠纤维蛋白原浓度略微增加（对照中2.75±0.7 Vs 1.9±0.5mg / ml）。然而，在NSE的作用下，CRD喂养大鼠（65±16 vs 100±11％）下降的抗凝血PC的水平（65±16±11％）（92±17％）。 NSE也影响了主动脉架构，然而，正常化主动脉瓦尔的厚度没有改变主动脉介质内的胆固醇诱导的夹杂物。 NSE抗炎作用改变CRD喂养大鼠的静血电过程，主要保护PC免受炎症过程中的消费和减少主动脉的水肿。然而，在NSE应用上独立地改变了血液学参数（包括APTT测试和纤维蛋白原浓度的凝血时间）。 NSE对血小板上的抗聚合作用可能是对血小板直接作用的结果或其抗炎作用的结果。在该模型中CRD诱导的血液发生期间，NSE在血液发生期间证明了保护生物体的有价值的抗炎作用，但是它不能被认为是抗血栓形成或抗真菌剂，因为它不能直接影响止血。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号