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首页> 外文期刊>Polymers >Individual Impact of Distinct Polysialic Acid Chain Lengths on the Cytotoxicity of Histone H1, H2A, H2B, H3 and H4
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Individual Impact of Distinct Polysialic Acid Chain Lengths on the Cytotoxicity of Histone H1, H2A, H2B, H3 and H4

机译：不同的聚脲酸链长度对组蛋白H1，H 2，H2b，H3和H4细胞毒性的单独影响

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Neutrophils are able to neutralize pathogens by phagocytosis, by the release of antimicrobial components, as well as by the formation of neutrophil extracellular traps (NETs). The latter possibility is a DNA-meshwork mainly consisting of highly concentrated extracellular histones, which are not only toxic for pathogens, but also for endogenous cells triggering several diseases. To reduce the negative outcomes initiated by extracellular histones, different approaches like antibodies against histones, proteases, and the polysaccharide polysialic acid (polySia) were discussed. We examined whether each of the individual histones is a binding partner of polySia, and analyzed their respective cytotoxicity in the presence of this linear homopolymer. Interestingly, all of the histones (H1, H2A, H2B, H3, and H4) seem to interact with ???±2,8-linked sialic acids. However, we observed strong differences regarding the required chain length of polySia to bind histone H1, H2A, H2B, H3, and H4. Moreover, distinct degrees of polymerization were necessary to act as a cytoprotective agent in the presence of the individual histones. In sum, the outlined results described polySia-based strategies to bind and/or to reduce the cytotoxicity of individual histones using distinct polySia chain length settings.
机译：中性粒细胞能够通过吞噬抗微生物组分的吞噬作用来中和病原体，以及通过形成中性粒细胞细胞外疏水阀（网）。后一种可能性是一种具有高度浓缩的细胞外组蛋白的DNA-Meshwork，这不仅对病原体有毒，而且还用于引发几种疾病的内源细胞。为了减少细胞外组蛋白引发的负蛋白，讨论了抗针对组蛋白，蛋白酶和多糖的抗体等不同方法。我们检查了每个单个组蛋白是否是多血症的结合伴侣，并在这种线性均聚物存在下分析它们各自的细胞毒性。有趣的是，所有的组蛋白（H1，H 2 A，H 2B，H 3和H4）似乎与α2,8-连接的唾液酸相互作用。然而，我们观察到有关具有结合组蛋白H1，H 2，H 2B，H 3和H4的多脂链长度的强烈差异。此外，在各种组蛋白存在下，必须在存在下作为细胞保护剂的不同程度的聚合。总之，概述的结果描述了使用不同的多晶素链长度设置结合和/或减少个体组蛋白的细胞毒性的基于多脂的策略。

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