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首页> 外文期刊>Polymers >Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery
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Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery

机译：基于环糊精和聚（环氧乙烷）的超分子纳米结构：用于药物递送的合成，结构表征和应用

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摘要

Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host–guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompatible polymer. Depending on the molecular weight, PEO can be used as a plasticizer or as a toughening agent. Moreover, the hydrogels of PEO are also extensively studied because of their outstanding characteristics in biological drug delivery systems. These biomaterials based on CD and PEO for controlled drug delivery have received increasing attention in recent years. In this review, we summarize the recent progress in supramolecular architectures, focusing on poly(pseudo)rotaxanes, vesicles and supramolecular hydrogels based on CDs and PEO for drug delivery. Particular focus will be devoted to the structures and properties of supramolecular copolymers based on these materials as well as their use for the design and synthesis of supramolecular hydrogels. Moreover, the various applications of drug delivery techniques such as drug absorption, controlled release and drug targeting based CD/PEO supramolecular complexes, are also discussed.
机译：通过宿主访客的相互作用，环糊精（CDS）被广泛地研究了药物输送载体。基于CD的聚（伪）旋刀，其由具有或没有庞大的基团（或塞子）的聚合物链上的一个或多个CD环穿线组成，引起了对超分子生物材料的发展的兴趣。聚（环氧乙烷）（PEO）是水溶性的生物相容性聚合物。取决于分子量，PEO可用作增塑剂或作为增韧剂。此外，由于生物药物输送系统中的出色特征，PEO的水凝胶也被广泛研究。近年来，基于CD和PEO的基于CD和PEO的生物材料得到了越来越多的关注。在本文中，我们总结了超分子架构中的最近进展，重点是基于CD和PEO用于药物递送的Poly（假型）旋油烷，囊泡和超分子水凝胶。特别是基于这些材料的超分子共聚物的结构和性能，以及它们用于超分子水凝胶的设计和合成的用途和性质。此外，还讨论了药物递送技术的各种应用，例如药物吸收，控制释放和基于CD / PEO超分子复合物的药物吸收技术。

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